Holton Taxol total synthesis精品分析.docVIP

Holton Taxol total synthesis From Wikipedia, the free encyclopedia Jump to: HYPERLINK /wiki/Holton_Taxol_total_synthesis \l column-one navigation, HYPERLINK /wiki/Holton_Taxol_total_synthesis \l searchInput search Holton HYPERLINK /wiki/Taxol_total_synthesis \o Taxol total synthesis Taxol total synthesis overview from raw material perspective The Holton Taxol total synthesis, published by HYPERLINK /wiki/Robert_A._Holton \o Robert A. Holton Robert A. Holton and his group at HYPERLINK /wiki/Florida_State_University \o Florida State University Florida State University in 1994 was the first HYPERLINK /wiki/Total_synthesis \o Total synthesis total synthesis of HYPERLINK /wiki/Taxol \o Taxol Taxol (generic name: paclitaxel) HYPERLINK /wiki/Holton_Taxol_total_synthesis \l cite_note-0 \o [1] HYPERLINK /wiki/Holton_Taxol_total_synthesis \l cite_note-1 \o [2] HYPERLINK /wiki/Holton_Taxol_total_synthesis \l cite_note-2 \o [3]. The Holton HYPERLINK /wiki/Taxol_total_synthesis \o Taxol total synthesis Taxol total synthesis is a good example of a HYPERLINK /wiki/Linear_synthesis \o Linear synthesis linear synthesis starting from commercially available natural compound HYPERLINK /w/index.php?title=Patchoulene_oxideaction=editredlink=1 \o Patchoulene oxide (page does not exist) patchoulene oxide. This HYPERLINK /wiki/Epoxide \o Epoxide epoxide can be obtained in two steps from the terpene HYPERLINK /wiki/Patchoulol \o Patchoulol patchoulol and also from HYPERLINK /wiki/Borneol \o Borneol borneol. The reaction sequence is also HYPERLINK /wiki/Enantioselective \o Enantioselective enantioselective, synthesizing (+)-Taxol from (-)-patchoulene oxide or (-)-Taxol from (-)-borneol with a reported HYPERLINK /wiki/Specific_rotation \o Specific rotation specific rotation of +- 47° (c=0.19 / MeOH). The Holton sequence to Taxol is relatively short compared to that of the other groups with an estimated 37 step not counting the addition of the amide tail. One of the reasons