妊娠期糖尿病与新生儿胰岛素抵抗相关性研究.docVIP

妊娠期糖尿病与新生儿胰岛素抵抗相关性研究 　　[摘要] 目的 探讨母亲妊娠期糖尿病（GDM）对子代胰岛素抵抗的影响，为改善子代生长发育提供依据。 方法 依据产妇是否合并妊娠期糖尿病把60例新生儿分为GDM组及对照组，每组各30例；检测新生儿脐血血糖（BG）、脐血糖化红蛋白（HbAlc）、脐血胰岛素（Ins）、出生体重，计算出每例新生儿胰岛素抵抗指数，分析妊娠期糖尿病与子代胰岛素抵抗的关系。 结果 GDM组母亲孕前体重及产前体重分别为（57.83±9.32）kg、（74.28±10.09）kg，新生儿出生体重（3.81±0.25）kg，而?φ兆榉直鹞?（53.61±8.45）kg、（68.77±8.76）kg、（3.13±0.55）kg，差异有统计学意义（P0.05）。GDM组平均胰岛素抵抗指数为（1.49±0.39），对照组为（0.86±0.11），两组之间差异有统计学意义（P0.05）。结论 母亲妊娠期糖尿病增加子代胰岛素抵抗，值得关注。 　　[关键词] 妊娠期糖尿病；糖尿病母亲；新生儿；胰岛素抵抗 　　[中图分类号] R714.2 [文献标识码] A [文章编号] 1673-9701（2018）03-0012-03 　　Correlation between gestational diabetes mellitus and neonatal insulin resistance 　　SHEN Wenxia 　　Shaoxing Maternal and Child Health Hospital in Zhejiang Province， Shaoxing 312000， China 　　[Abstract] Objective To investigate the influence of maternal gestational diabetes mellitus （GDM） on insulin resistance in children and to provide basis for improving the growth and development of children. Methods According to whether pregnant women had gestational diabetes mellitus or not，60 newborns were divided into GMD group and control group， with 30 cases in each group. The levels of neonatal umbilical blood glucose（BG）， umbilical cord blood glycosylated hemoglobin （HbAlc）， umbilical blood insulin（Ins）， birth weight were detected. And the insulin resistance index of each newborn was calculated. The correlation between the gestational diabetes mellitus and neonatal insulin resistance was analyzed. Results The body weight of mothers before pregnancy and delivery and newborn birth weight in the GDM group was（57.83±9.32）kg， （74.28±10.09）kg and （3.81±0.25）kg， respectively， while those in the control group was（53.61±8.45）kg， （68.77±8.76）kg and（3.13±0.55）kg， respectively. The differences in the above data between the two groups were statistically significant（P0.05）. The mean insulin resistance index was （1.49±0.39） in GDM group and （0.86±0.11） in control group， with significant difference between the two groups（P0.05）. Conclusion Gestational diabetes in mothers i