妊娠各期及新生儿EB病毒感染情况及母婴垂直传播初步研究.docVIP

妊娠各期及新生儿EB病毒感染情况及母婴垂直传播初步研究 　　【摘要】 目的 探讨产妇妊娠各期及新生儿EB病毒感染情况及母婴垂直传播状况， 为新生儿EB病毒感染的预防及新生儿结局的改善提供依据。方法 120例单胎妊娠孕产妇， 检测其妊娠早期、妊娠中期和妊娠晚期的EB病毒感染情况及其新生儿EB病毒感染情况， 比较母亲不同时期EB病毒感染及不同分娩方式新生儿的EB病毒感染情况和不同EB病毒感染情况新生儿的结局。结果 120例孕产妇EB病毒感染率为28.33%， 其中妊娠早期EB病毒感染率低于妊娠中期和妊娠晚期（P0.05）。顺产和剖宫产新生儿EB病毒感染率比较差异无统计学意义（P0.05）。与出现EB病毒感染的新生儿比较， 无EB病毒感染的新生儿畸形、低体质量等不良结局的发生率降低（P0.05或P0.01）。结论 EB病毒感染率随着妊娠过程的进展而增加， 其新生儿的EB病毒感染率高且可影响新生儿结局；EB病毒可经母婴垂直传播途径引发新生儿EB病毒感染， 剖宫产无法减少新生儿EB病毒感染；妊娠期间尤其是妊娠晚期注意对EB病毒感染的防控有利于减少新生儿EB病毒感染和改善新生儿结局。 　　【关键词】 妊娠各期；新生儿；EB病毒；母婴垂直传播；新生儿结局 　　【Abstract】 Objective To investigate newborn EB virus infection and mother-to-child vertical transmission in pregnancy periods， in order to provide reference for preventing newborn EB virus infection and improving neonatal outcome. Methods Detection of EB virus infection was made in 120 single pregnancy women in the first， second and third trimester of pregnancy and their newborn infection condition. Comparison was made on newborn EB virus infection and neonatal outcome of different infection period and delivery ways. Results Infection rate of EB virus was 28.33% in 120 pregnant women， and the infection rate in first trimester was lower than second and third trimester （P0.05）. The difference of newborn infection rate of EB virus between natural labour and cesarean section had no statistical significance （P0.05）. Comparing with EB virus infected newborn， those without EB virus infection had lower incidence of neonatal malformation and lower body mass （P0.05 or P0.01）. Conclusion Infection rate of EB virus increases along with pregnancy progress， and high newborn infection rate will influence neonatal outcome. Mother-to-child vertical transmission will lead to newborn infection of EB virus， which cannot by reduced by cesarean section. Prevention of EB virus infection during pregnancy periods， especially third trimester， is helpful for reducing newborn EB virus infection and improving neonatal outcome. 　　【Key words】 Pregnancy periods； Newborn；