宫腔注药联合孕激素治疗子宫内膜息肉临床研究.docVIP

宫腔注药联合孕激素治疗子宫内膜息肉临床研究 　　【摘要】 目的 探讨宫腔注药联合孕激素治疗子宫内膜息肉的临床效果。方法 选取子宫内膜息肉患者113例，术后随机分为2组：对照组54例，术后给予安宫黄体酮治疗3个月；治疗组59例，在月经干净3 d用地塞米松+洁霉素+糜蛋白酶+0.9%氯化钠注射液20 ml宫腔注药，共3 d，术后给予共3个月。2组随访时间为3~6个月，观察子宫内膜息肉复发情况。结果治疗组59例中治愈43例，复发7例。对照组54例中治愈48例，复发18例。两组结果治愈率差异无统计学意义（P＞0.05），复发率有统计学意义（P＜0.05）。结论 子宫内膜息肉的患者进行宫腔注射地塞米松、洁霉素、糜蛋白酶联合孕激素治疗，此法安全可靠、痛苦小、疗效好。? 　　【关键词】 安宫黄体酮；子宫内膜息肉；宫腔注药?? 　　The clinical research of intrauterine injection techniqueand progestin for endometrial polyps 　　 　　YANG Xiao?mei, REN Wei?ru. 　　The Third Hospital of Zaozhuang City,Shandong 277100, China 　　? 　　【Abstract】 Objective To explore the clinical effect of intrauterine injection technique and progestion for endometrial polyps. Methods 113 cases of endometrial polyps were randomly divied into the control group and treatment group54 cases were given to Medroxyprogesterone Acetate for 3 months in control group. 59 cases 　　?? 　　作者单位：277100山东省枣庄市立三院? 　　 were given to Dexamethasone + Lincomycin + Chymotrypsin +NS normal saline (20 ml) for 3 days, and treat 3 months. 2 groups followed up for 3～6 months to observe recurrence of endometrial polyps. Results The 41 cases were cured, recurrence in 9 cases in treatment group.. 48 patients were cured s, 32 cases of recurrence In control group.Two groups was no significant difference in cure rate (P0.05), relapse rates were significantly different (P0.05),Conclusion Endometrial polyps in patients with intrauterine injection of Dexamethasone, Lincomycin, Chymotrypsin and progestin combined therapy, this method safe reliable, pain small, the curative effect is good. ? 　　【Key words】 Medroxyprogesterone Acetate;Endometrial polyps；Intrauterine injection technique 　　?1 资料与方法? 　　1.1 一般资料 对于我院经宫腔镜诊断联合病理确诊的子宫内膜息肉的患者，月经干净3 d，应用地塞米松、洁霉素、糜蛋白酶宫腔注射连续3 d，同时口服孕激素1个月后复查宫腔镜，观察内膜息肉缩小情况，1个月为一个疗程，连用三个疗程。? 　　选取2008年8月至2010年9月子宫内膜息肉的患者113例，年龄28~47岁，平均(30.2±6)岁，术后随机分为2组：对照组54例宫腔镜检查诊断子宫内膜息肉后，经诊刮送病理确诊子宫内膜息肉后，术后给予安宫黄体酮治疗3月；治疗组59例，宫腔镜检查诊断子宫内膜息肉后，经诊刮送病理确诊子宫内膜息肉后，给予宫腔注药+安宫黄体酮口服治疗共3个月。2组随访时间为3~6个月