米非司酮在功能失调性出血中的应用.docVIP

米非司酮在功能失调性出血中的应用 　　摘要：目的：研究米非司酮在治疗功能失调性出血中的应用情况，为临床用药工作提供必要的参考与借鉴。方法：选取我院于2009年7月份至2010年7月份收治的100例功能失调性出血患者，将其作为研究对象，对其临床资料进行回顾性分析。采取对比试验的方法，随机将患者分为对照组与观察组，对照组应用妈富隆，观察组应用米非司酮，治疗持续3个月。研究患者在治疗前后的相关激素水平变化，并观察不良反应情况，通过无效、有效、显效的标准，评价临床疗效，进行对比分析。结果：对照组与观察组各出现6例、5例不良反应，比较差异P0.05，不具统计学意义。所有患者的雌二醇、孕酮、黄体生成素、卵泡刺激素水平均显著下降，比较差异P0.05，具有统计学意义，且对照组数值均高于观察组，比较差异P0.05，具有统计学意义。观察组共48例（96.0%）治疗有效，对照组共41例（82.0%）治疗有效，比较差异P0.05，具有统计学意义。结论：针对功能失调性出血，应用米非司酮，能够收到显著的治疗效果，且不易引发不良反应，适于在临床领域得到进一步的推广。 　　关键词：功能失调性出血；米非司酮；对比分析 　　The application of mifepristone on dysfunctional tonal bleeding 　　Cheng ShaoboLi Fangfei 　　Abstract：Objective：to study the mifepristone in the treatment of dysfunctional application of tonal bleeding， provide necessary reference for clinical medication work with draw lessons from. Methods：select our hospital from July 2009 to July 2009 treated 100 patients with dysfunctional tonal bleeding， as the research object， the clinical data were retrospectively analyzed. Take the contrast test， the method of patients randomly divided into control group and observation group， control group applied mom rich grand， observation group application， mifepristone treatment for 3 months. Research in the treatment of patients with related hormone levels before and after the change， and to observe the adverse reaction case， through the void， effective and standard were markedly improved， evaluate the clinical curative effect， were analyzed. Results： the control group and observation group in 6 cases， 5 cases of adverse reactions， comparative difference P0.05， no statistical significance. All of the patients of estradiol， progesterone， luteinizing hormone and follicle-stimulating hormone levels were significantly decreased， comparative differences P0.05， statistically significant values were higher than in observation group and control group， comparing differences P0.05， with statistical significance. Group a total of 48 cases （96.0%）， effective treatment， control group a total of 41 case