探讨舍曲林联合利培酮治疗精神分裂症阴性症状疗效和安全性.docVIP

探讨舍曲林联合利培酮治疗精神分裂症阴性症状疗效和安全性 　　【摘要】 目的：探究舍曲林联合利培酮治疗精神分裂症阴性症状的疗效和安全性。方法：随机选取2014年5月-2016年5月本院收治的精神分裂症患者中116例进行临床分析，按照随机数字表法将其分为对照组和探讨组，各58例。其中对照组单独使用利培酮治疗，探讨组使用舍曲林联合利培酮治疗，观察统计两组临床疗效和不良反应发生情况。结果：探讨组治疗总有效率明显优于对照组，差异有统计学意义（P0.05）；治疗后，探讨组各项阴性症状评分均低于对照组，差异均有统计学意义（P0.05）。结论：针对精神分裂症阴性症状患者而言，可通过舍曲林联合利培酮治疗，效果突出，安全性较高，可推广使用。 　　【关键词】 舍曲林； 利培酮； 精神分裂症； 阴性症状； 疗效； 安全性 　　【Abstract】 Objective：To explore the clinical effect and safety of Sertraline combined with Risperidone in the treatment of negative symptoms of schizophrenia.Method：116 cases of schizophrenia and who accepted treatments in our hospital from May 2014 to May 2016 were randomly selected for clinical analysis，they were divided into the control group and the study group according to the law of numerical method，58 cases in each group.The control group was treated with Risperidone alone，while the study group was treated with Sertraline combined with Risperidone.The clinical effects and adverse reactions of two groups were observed and counted.Result：The total of effective rate of the study group was significantly better than that of the control group，the difference was statistically significant（P0.05）.After treatment，the scores of negative symptoms of the study group were lower than those of the control group，the differences were statistically significant（P0.05）.Conclusion：For patients with negative symptoms of schizophrenia，Sertraline can be combined with Risperidone treatment，and the effect is prominent，the safety is high，thus it can be widely used. 　　【Key words】 Sertraline； Risperidone； Schizophrenia； Negative symptoms； Clinical effect； Safety 　　First-author’s address：Qishan Hospital in Panyu District of Guangzhou City，Guangzhou 511483，China 　　doi：10.3969/j.issn.1674-4985.2017.29.027 　　精神分裂?Y发病原因具有一定复杂性，与患者突然的情感压抑以及精神刺激存在密切联系，主要以行为、思维和情感异常为临床表现[1-2]。精神分裂症根据症状可分为阴性和阳性症状，其中阳性症状给予合理治疗可明显改善，而阴性症状由于相对隐秘难以察觉，因此在诊治过程中极易被忽略，为后期复发提供了机会，以及演变为病残的主要因素[3-4]。本研究探究了舍曲林联合利培酮治疗精神分裂症阴性症状的疗效和安全性，现报道如下。 　　1 资料与方法 　　1.1 一般资料 在本院201