武汉大学 分子生物学全部课程 3.pptVIP

Welcome Each of You to My Molecular Biology Class CHAPTER 6 The Structures of DNA and RNA DNA STRUCTURE (1) Local disruption of base pairs Function (1): DNA in cells is negatively supercoiled; nucleosomes introduces negative supercoiling in eukaryotes Negative supercoils serve as a store of free energy that aids in processes that require strand separation, such as DNA replication and transcription. Strand separation can be accomplished more easily in negatively supercoiled DNA than in relaxed DNA DNA TOPOLOGY (3) Function (2): Topoisomerases (P115-119) The biological importa