毕业论文（设计）年产1.2亿盐酸美西律片（50mg）车间工艺设计.docVIP

PAGE \* MERGEFORMAT PAGE \* MERGEFORMAT II 年产1.2亿盐酸美西律片（50mg）车间工艺设计 摘 要：盐酸美西律片的归类是Ib类抗心律失常药，主要用于急、慢性室性心律失常，如室性早搏、室性心动过速、心室颤动及洋地黄中毒引起的心律失常。由于片剂的良好吸收，稳定性高等优点成为盐酸美西律的主要剂型。 确定合理的处方设计，设计制备该制剂的工艺流程，并通过物料衡算，按照实际生产能力选择出各个流程所需的生产设备和型号，并根据生产要求设计车间，使其符合GMP要求。该工艺合理，设备简单，车间布局合理，符合设计要求。 关键词：盐酸美西律片；工艺流程；物料衡算； 设备选型；车间设计 PAGE \* MERGEFORMAT PAGE \* MERGEFORMAT II With an annual output of 120 million Mexiletine hydrochloride Tablets(50mg) design workshop Xia lei (School?of?Chemistry?and?Chemical?Engineering,?University?of?South?China,Hengyang,?Hunan,China?,421001)Tutor:?Wang yu yuan Abstract:Mexiletine?hydrochloride?tablets?are?the?anti-arrhythmic?drugs?of?1b?class,?mainly?used?to?against?acute?and?chronic?ventricular?arrhythmia,?such?as?the?arthythmia?caused?by?ventricular?premature?beat,?ventricular?tachycardia,?ventricular?fibrillation?and?digitalis?poisoning.?Due?to?the?tablets?can?be?absorbed?effectively?and?its?high?stability,?they??become?the?main?form?of?mexiletine?hydrochloride.?According?to?the?actual?production?capacity?and?the?production?requirements,?we?can?choose?the?equipments?and?their?model?in?each?process?and?design?workshops?through?ensuring?a?reasonable?prescription?design,?designing?the?craft?process?of?preparation,?and?the?material?balance?to?meet?the?GMP?requirements.?Its?reasonable?process?and?workshop?layout?and?its?simple?equipment?meet?the?requirements?of?the?design. Keywords：Mexiletine?hydrochloride?tablets?；Technological process；?material balance；?Plant model selection；Workshop design PAGE \* MERGEFORMAT PAGE \* MERGEFORMAT III 目录 TOC \o 1-3 \h \u HYPERLINK \l _Toc23333 引 言 PAGEREF _Toc23333 1 HYPERLINK \l _Toc29864 盐酸美西律的介绍 PAGEREF _Toc29864 2 HYPERLINK \l _Toc4333 设计的目的、意义 PAGEREF _Toc4333 2 HYPERLINK \l _Toc25448 1.指导思想和设计原则 PAGEREF _Toc25448 3 HYPERLINK \l _Toc4360 1.1指导思想 PAGEREF _Toc4360 3 HYPERLINK \l _Toc2080 1.2 设计原则 PAGEREF _Toc2080 3 HYPERLINK \l _Toc5467 1.2.1工艺流程设计 PAGEREF _Toc5467 3 HYPERLIN