深圳市孕妇鼻腔定植SA和MRSA耐药谱分析.docVIP

深圳市孕妇鼻腔定植SA和MRSA耐药谱分析 　　【摘要】 目的：了解深圳市孕妇鼻腔定植的金黄色葡萄球菌（SA）和耐甲氧西林金黄色葡萄球菌（MRSA）的耐药谱情况。方法：收集深圳市龙华新区人民医院及中心医院入院待产孕妇鼻腔分离出的SA菌株，并采取纸片扩散法确定MRSA菌株和SA耐药情况。结果：共收集了SA 547株，其中MRSA 107株。MRSA对克林霉素、利福平、红霉素、青霉素及多重耐药的耐药情况与MSSA比较，差异均有统计学意义（P0.001、P0.001、P0.001、P=0.012、P0.001）。对孕妇的年龄进行分组后，可见不同年龄组对利福平、妥布霉素、红霉素、青霉素、替考拉宁、复方新诺明及多重耐药的耐药情况比较，差异均有统计学意义（P0.001、P=0.012、P=0.034、P=0.009、P=0.008、P=0.004、P=0.003）。结论：本研究中孕妇鼻腔携带的SA和MRSA菌株的耐药率较高。另外，高龄孕妇和低龄孕妇的MRSA耐药性较严重应引起注意。 　　【关键词】 耐甲氧西林金黄色葡萄球菌； 孕妇； 耐药 　　Antibioti-resistance Spectrum Analysis of SA and MRSA in the Nasal Colonization of Pregnant Women in Shenzhen City/PENG Ru-jiao，LIN Jia-ling，YAN Chun-rong，et al.//Medical Innovation of China，2016，13（33）：058-061 　　【Abstract】 Objective：To understand the antibiotic-resistance spectrum of Staphylococcus aureus （SA） and methicillin-resistant Staphylococcus aureus （MRSA） in the nasal colonization of pregnant women in Shenzhen city.Method：SA isolates were collected from nasal cavity of pregnant women from the People’s Hospital and Central Hospital of Longhua New District in Shenzhen，the antibiotic-resistance of MRSA and SA were determined by disk diffusion method.Result：A total of 547 SA isolates were collected and 107 were MRSA isolates.There were significant differences between MRSA and MSSA with regard to Clindamycin，Rifampicin，Erythromycin，Penicillin，and multidrug resistance（P0.001，P0.001，P0.001，P=0.012，P0.001）.After stratified by the age，the different age groups to Rifampin，Tobramycin，Erythromycin，Penicillin，Teicoplanin，comparison of Compound Sulfamethoxazole Tablets and multiple antibioti-resistance，the differences were statistically significant（P0.001，P=0.012，P=0.034，P=0.009，P=0.008，P=0.004，P=0.003）.Conclusion：The proportions of antibiotic resistance in SA and MRSA among pregnant women are high.In addition，the antibiotic-resistance of MRSA in older pregnant women and young pregnant women are more severe and should be paid attention. 　　【Key words】 MRSA； Pregnant woman； Antibioti-resistant 　　First