腹腔镜贲门癌手术对贲门癌患者hs―CRPT淋巴细胞亚群及免疫球蛋白影响机制研究.docVIP

腹腔镜贲门癌手术对贲门癌患者hs―CRPT淋巴细胞亚群及免疫球蛋白影响机制研究 　　[摘要] 目的 研究腹腔镜贲门癌手术对患者hs-CRP、T淋巴细胞亚群及免疫球蛋白的影响。 方法 选择2009年12月～2015年12月我院治疗的贲门癌患者60例，根据手术方式的不同随机分为两组：其中腹腔镜组30例，余30例行开腹手术为对照组，比较两组贲门癌患者手术前后hs-CRP、调节性T细胞及免疫球蛋白水平的变化。 结果 腹腔镜组hs-CRP水平术后3、7 d分别显著低于对照组，腹腔镜组患者术后7 d外周血CD3+、CD4+、CD4+/CD8+活性恢复至接近术前水平（P0.05），而对照组仍显著低于腹腔镜组（P0.05）。对照组术后3、7 d的IgM水平分别显著低于腹腔镜组（P0.05）。 结论 腹腔镜贲门癌手术对hs-CRP及T淋巴细胞亚群与免疫球蛋白的变化较开腹手术变化小，对机体的免疫抑制轻，能更好地保护患者的免疫功能，且可以减轻术后急性期反应，有效避免术后因免疫导致的感染等并发症的发生，有利于促进患者术后尽快恢复。 　　[关键词] 腹腔镜手术；贲门癌；hs-CRP；T淋巴细胞亚群；免疫球蛋白 　　[中图分类号] R735.2 [文献标识码] A [文章编号] 1673-9701（2016）13-0012-04 　　Influencing mechanism research of laparoscopic cardiac cancer surgery on hs-CRP， T lymphocyte subsets and immune globulin 　　WANG Zhiyan CHEN Ting WANG Yong WU Biao 　　Department of Surgery， Yinzhou Second Hospital of Ningbo City， Ningbo 315100， China 　　[Abstract] Objectives To explore the influence of laparoscopic cardiac cancer surgery on hs-CRP， T lymphocyte subsets and immune globulin of patients. Methods 60 patients with cardiac cancer treated in our hospital from December 2009 to December 2015 were selected and divided according to operation methods into two groups： the laparoscope group （30 patients） and the open surgery group（30 patients）. The changes of levels of hs-CRP， regulatory T cell， and immune globulin were compared between two groups. Results The level of hs-CRP was significantly lower in the laparoscope group than in the open surgery group at 3 days and 7 days after operation. In the laparoscope group， the activity of CD3+， CD4+， CD4+/CD8+ in peripheral blood recovered nearly to that before operation at 7 days after operation（P0.05）， and the control group was significantly lower than that in laparoscope group（P0.05）. The levels of IgM in the control group at 3 days and 7 days after operation were respectively significantly lower than those in the laparoscope group（P0.05）. Conclusion Laparoscopic cardiac cancer surgery leads to slighter changes in hs-CRP， T lymphocyte subsets and immune globu