安心颗粒防治冠心病介入术后再狭窄的临床研究中西医结合;临床专业论文.docxVIP

PAGE PAGE 10 Clinical Research for Effeets of Anxin granula on Re s te no s i s after PCI ABSTRACT Objective: To object the effect of Anxin granula to patients with coronary heart disease in restenosis rate, significant cardiovascular event incidence rate, clinical symptom, heart function, lipid, inter-leukin-8 and high sensitive C reactionprotein after PCI. Research the curative effect and mechanism of Anxin granules curung restenosis after PCI. Methods: Sixty patients with coronary heart disease after PCI were randomly into trial group and control group , each group had 30 patients. The patients in the control group received regular western medicine therapy, the other patients in the trial group received the treatment of Anxin granula and conventional western medicine, two groups were all treated for six months. After the course of treatment, survey the restenosis rate and the cardiovascular even incidence rate in six months, clinical symptom and sigh, heart function, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol changes, and PCI pre-and-post month IL-18 and hs-CRP level changes. Result: Sixty patients were received in this research. In six month of PCI, the trial group has two cases of restenosis, the control group has three cases of restenosis, there is no difference between two groups（P 0.05）. During the treatment, the trial group occurs one adverse cardiac events, the control group occurs eight adverse cardiac events, this two group has difference (P 0.05). After the treatment, two groups the symptoms integral in trial pre-and-post and clinical total effective rate, the trial group surpasses control group(P 0.01＆P 0.05). the blood fat, the normal ventricular wall movement section and LVEF exist difference obviously. The trial group has an advantage to control group （P 0.01＆P 0.05）. Preoperative and postoperative month IL-18 and Hs-CRP trial group lower level than the control group(P 0.01)