葛根素治疗糖尿病肾病临床观察.docVIP

葛根素治疗糖尿病肾病临床观察 　　[摘要] 目的 观察葛根素对糖尿病肾病的临床效果。方法 选择本院2010年1月～2012年12月收治的108例糖尿病肾病患者，随机分为治疗组54例，对照组54例，两组均予常规降糖、降压、降血脂治疗，治疗组加用以葛根素注射液400mg加入0.9%氯化钠注射液500mL中静脉滴注。每日1次，4周为1个疗程，观察两组治疗前后的尿微量蛋白、血肌酐、血尿素氮、血流变检测结果。结果 对照组患者治疗前24h尿蛋白定量（0.35±0.17）g/24h，肌酐（135.8±27.6）μmol/L，尿素氮（13.4±3.5）mmol/L。治疗组患者治疗前24h尿蛋白定量（0.34±0.16）g/24h，肌酐（136.1±26.9）μmol/L，尿素氮（13.5±3.3）mmol/L等差异无统计学意义（P0.05）。两组患者治疗后对照组24h尿蛋白定量（0.23±0.10）g/24h，肌酐（109.9±18.9）μmol/L，尿素氮（11.6±2.9）mmol/L。治疗组24h尿蛋白定量（0.15±0.07）g/24h，肌酐（105.9±17.9）μmol/L，尿素氮（10.2±2.4）mmol/L。两组治疗后24h尿蛋白定量、肌酐、尿素氮均下降，但治疗组TP/24h与对照组比较下降有显著差异（P0.05）。两组治疗后血流变检测结果显示对照组血小板聚集率（76.7±15.1）%、全血黏度（10.27±1.16）mPa?s、血浆黏度（10.12±1.01）mPa? s。治疗组血小板聚集率（38.9±9.3）%、全血黏度（5.31±1.03）mPa?s、血浆黏度（5.16±1.18）mPa ?s。两组比较下降有显著差异（P0.05）。结论 葛根素静脉滴注可降低糖尿病肾病蛋白尿，改善肾功能；可抑制血小板聚集、降低患者血液的高黏状态。 　　[关键词] 糖尿病肾病；葛根素；尿微量蛋白 　　[中图分类号] R587.2 [文献标识码] B [文章编号] 2095-0616（2013）22-86-03 　　Puerarin treatment of diabetic nephropathy 　　YAN Dong 　　Jiangsu Province Siyang Peoples Hospital， Siyang 223700，China 　　[Abstract] Objective To observe the clinical effect of Puerarin treatment on diabetic nephropathy. Methods 108 cases of diabetic nephropathy patients in our hospital from 2010 January to 2012 December were selected and randomly divided into the treatment group of 54 cases， the control group of 54 cases.The two groups were given conventional hypoglycemic， hypotensive， lipid-lowering therapy， treatment group was added with 0.9% sodium chloride injection 500mL by intravenous drip with puerarin injection 400mg，once a day， 4 weeks as a course of treatment.The indexes such as the urine protein， serum creatinine， blood urea nitrogen，blood rheology detection results were observed before and after treatment in two groups. Results Before treatment， the indexes of patients in the control group were as follows，24 hour urinary protein quantitative （0.35±0.17）g/24h，creatinine （135.8±27.6）μmol/L，urea nitrogen （13.4±3.5）mmol/L.While the indexes of patients in the treatment group were as follows 24 hour urin