芪红解郁方治疗慢性心力衰竭合并抑郁症临床研究.docVIP

芪红解郁方治疗慢性心力衰竭合并抑郁症临床研究 　　摘要：目的探讨芪红解郁方治疗慢性心力衰竭（CHF）合并抑郁症患者的临床疗效。方法将120例慢性心力衰竭合并抑郁症患者采用随机数字法分为对照组和观察组，各60例。观察组给予芪红解郁方加减，对照组服用帕罗西汀片加减，治疗期间均给予患者心理辅导干预8周，其后每2个月进行一次随访，共随访3次。结果观察组Lee氏心衰疗效总有效率为86.67%，优于对照组的71.67%（Plt;0.05）;观察组抑郁症疗效总有效率88.33%，对照组为81.67%，组间比较差异无统计学意义（Pgt;0.05）;治疗后观察组Lee氏心衰评分、汉密尔顿抑郁量表（HAMD）评分均低于对照组（Plt;0.01）;观察组左室射血分数（LVEF）和心搏出量（CO）高于对照组（Plt;0.01）;观察组N端脑钠肽前体（NTproBNP）水平低于对照组（Plt;0.01）;对照组不良反应发生率高达58.3%，观察组未发现明显不良反应。结论芪红解郁方对CHF合并抑郁症患者能够改善临床症状及心功能，改善患者实际生活能力并能促进心理康复的过程。 　　关键词：慢性心力衰竭;芪红解郁方;抑郁;心功能 　　中图分类号：R541R289文献标识码：A 　　doi：10.3969/j.issn2015.01.006 　　文章编号2015 　　Effect of Qihong Jieyu Decoction for Treatment of Chronic Heart Failure Complicated with Depression 　　Fan Hui，Li Chao，He Xiuli，Wang Xiaofeng 　　The Hospital of Traditional Chinese Medicine，Xinjiang Medical University， Urumqi 830000，Xinjiang，China 　　Corresponding Author：Wang Xiaofeng 　　Abstract：ObjectiveTo evaluate the clinical efficiency of Qihong Jieyu decoction （QJD） for treatment of chronic heart failure complicated with depression（CHFD）.MethodsOne hundred and twenty patients with CHFD were randomized by digital table into two groups：The control group （n=60） treated by paroxetine and the observation group（n=60） treated with QJD for 8 weeks. 　　Results The total efficiency of Lee’s heart failure was 86.67% in observation group，which was higher than that in control group（71.67%，Plt;0.05）.The total efficiency of depression was 88.33% in observation group and 81.67% in control group（71.67%，Plt;0.05）.There was no significant difference between the two groups（Pgt;0.05）.After treatment，Lee’s failure score and HAMD score in observation group were lower than that in control group （Plt;0.01）.The left ventricular end diastolic diameter（LVED）and cardiac output（CO）in observation group were better than that in control group（Plt;0.01）.The levels of Nterminal proBtype natriuretic peptide （NTproBNP） in observation group was lower than that in control group （Plt;0.01）.The advers