子宫内膜异位症、子宫腺肌病病理分析课件.ppt

* Modification of position 6 and 10 is typical for all GnRH agonists. This leads to a change in - GnRH receptor affinity (which is increased) - regulation of biologic activity (which is increased due to a longer half life) * Action of GnRH agonists 1. Binding of GnRH leads to a post-receptor-cascade and this consecuitively to the release of LH and FSH 2. Adding of GnRH agonists will lead - because they have a higher affinitiy to the receptors and have a higher biologic potency - to binding of the agonists to the receptors instead of the natural GnRH. 3. Initially, this will lead to an increase