血清胃蛋白酶原胃泌素与Hp相关性食管炎病情程度相关性评价.docVIP

血清胃蛋白酶原胃泌素与Hp相关性食管炎病情程度相关性评价 　　摘 要 目的：探讨血清胃蛋白酶原、胃泌素在幽门螺杆菌（Hp）感染相关性食管炎病情程度中的评估价值。方法：选取105例食管炎患者，其中细菌培养Hp阳性者作为Hp相关性食管炎组，Hp阴性者作为非Hp相关性食管炎组，采用ELISA法检测血清Hp-IgG 抗体、PGⅠ、PGⅡ、胃泌素含量和PGR （PGⅠ/ PGⅡ）水平，病情程度按内镜下食管黏膜病变程度分级（A、B、C、D级）。结果：食管炎分级越高，血清Hp-IgG 抗体阳性比例越高，其中A级食管炎患者Hp-IgG 抗体阳性比例明显低于D级食管炎患者，A、D级别比较差异具有统计学意义（P0.05），Hp相关性食管炎组PGⅠ、PGⅡ、胃泌素和PGR均明显低于非Hp相关性性食管炎组，两组比较差异均具有统计学意义（P0.05），且不同病情程度Hp相关性食管炎组患者PGⅠ、PGⅡ、胃泌素和PGR比较差异均有统计学意义（P0.05），其中A级最高，D级最低。结论：食管炎与Hp感染密切相关，血清胃蛋白酶原和胃泌素水平在Hp相关性食管炎患者中明显增高，且对其病情程度评估具有重要价值。 　　关键词 幽门螺杆菌感染 食管炎 胃蛋白酶原 胃泌素 　　中图分类号：R571 文献标识码：A 文章编号：1006-1533（2016）03-0051-03 　　Correlative evaluation of serum pepsinogen and gastrin with severity of Hp-related esophagitis 　　XIE Daigang*， WANG Beibei， XIAO Raojun 　　（Xiangyaping Mine Cooperation Hospital of Pingxiang City， Pingxiang 337000， China） 　　ABSTRACT Objective： To investigate the evaluation value of serum pepsinogen and gastrin in the severity of Helicobacter pylori （Hp）-related esophagitis. Methods： One hundred and five cases of patients with esophagitis were selected and divided into an Hp-related esophagitis group （Hp positive） and a none-Hp-related esophagitis group （Hp negative）. The contents of serum Hp-IgG antibody， PGⅠ， PGⅡand gastrin and PGR （PGⅠ/PGⅡ） levels were detected by ELISA method and the severity of disease was graded based on endoscopic esophageal mucosa lesion severity （A， B， C， D）. Results： The higher the classification of esophagitis， the higher the positive ratio of Hp-IgG serum antibody， the positive ratio of Hp-IgG antibody in patients with grade A esophagitis was significantly lower than grade D esophagitis （P0.05）， PGⅠ， PGⅡ， gastrin and PGR levels were significantly lower in the Hp-related esophagitis group than none-Hp-related esophagitis group（P0.05）， and a comparison of PGⅠ， PGⅡ， gastrin and PGR levels among different severity of Hp-related esophagitis patients showed statistical significance （P0.05）， in which the highest was grade A and the lowest was grade D. Conclusion： Esophagit