血清胰岛素瘦素及CRP在乳腺癌合并2型糖尿病患者中表达水平及其临床意义.docVIP

血清胰岛素瘦素及CRP在乳腺癌合并2型糖尿病患者中表达水平及其临床意义 　　【摘要】 目的：探究血清胰岛素、瘦素及C反应蛋白（CRP）在乳腺癌合并2型糖尿病患者中的表达水平及其临床意义。方法：选择2008-2015年入住本院进行治疗的120例患者为研究对象，根据研究参与者类型的不同，分为A组（乳腺癌合并糖尿病患者，40例）、B组（单纯乳腺癌患者，40例）、C组（单纯2型糖尿病患者，40例）；另选取主动参与本次研究的健康志愿者40例作为对照组。160例受试者均静脉采血，离心分离血清后，采用ELISA方法测定受检者血清LEP水平，采用酶联免疫测定法测定胰岛素及CRP水平。分别测定四组患者血清瘦素水平、空腹血浆胰岛素（FINS）、CRP指数，并进行统计学分析。结果：A组、B组、C组的血清胰岛素、瘦素、CRP的水平与对照组比较，差异均有统计学意义（P0.05）。结论：血清胰岛素、瘦素及CRP在乳腺癌合并2型糖尿病患者中具有显著的表达，三项指标对于乳腺癌合并2型糖尿病的早期诊断与治疗具有重大意义。 　　【关键词】 血清胰岛素； 瘦素； CRP； 乳腺癌合并2型糖尿病 　　Expression and Clinical Significance of Serum Insulin，Leptin and CRP in Breast Cancer Patients with Type 2 Diabetes Mellitus/GUO Wu-bin，MA Xin，LIU Xiang.//Medical Innovation of China，2017，14（03）：013-016 　　【Abstract】 Objective：To investigate the expression and clinical significance of serum insulin，leptin and C reactive protein（CRP） in breast cancer patients with type 2 diabetes mellitus.Method：120 patients in our hospital from 2008 to 2015 were selected as research subjects，according to the study participants of different types，they were divided into A group（40 cases with breast cancer combined with diabetes mellitus，B group（40 cases of breast cancer patients，C group（40 patients with type 2 diabetes mellitus），this study selected the active participation of 40 healthy volunteers as control group.160 cases were taken venous blood samples，centrifuged serum，ELISA method was used to determine the level of serum LEP，the level of insulin and CRP were measured by enzyme linked immunosorbent assay（ELISA）.The levels of serum leptin，fasting plasma insulin（FINS） and CRP index were measured and analyzed in four groups.Result：The serum insulin，leptin，CRP levels of A group，B group，C group compared with the control group，the differences were statistically significant（P0.05）.Conclusion：The serum insulin，leptin and CRP in breast cancer patients with type 2 diabetes have significant expression，the three indicators for breast cancer with type 2 diabetes early diagnosis and treatment is of great signifi