通心络胶囊对急性ST段抬高型心肌梗死患者hsCRP和ET1影响.docVIP

通心络胶囊对急性ST段抬高型心肌梗死患者hsCRP和ET1影响 　　[摘要] 目的 探讨通心络胶囊对ST段抬高的心肌梗死患者（STEMI）高敏C-反应蛋白（hs-CRP）和内皮素-1（ET-1）的影响。方法 110例符合纳入标准的急性ST段抬高型心肌梗死患者，随机分为观察组60例和对照组50例，对照组采用常规治疗手段治疗，观察组在此基础上加用通心络胶囊治疗。对比两组治疗前后高敏C-反应蛋白、内皮素-1及心功能变化情况。结果 治疗后观察组hs-CRP和ET-1下降均较对照组显著（P＜0.05或P＜0.01）；LVEF升高较对照组显著（P＜0.05），LVEDD、LVESD缩小较对照组显著（P＜0.05）。结论 通心络通过抑制STEMI患者的血管局部炎症反应，改善血管内皮细胞功能，降低hs-CRP和ET-1水平，从而稳定动脉粥样硬化斑块，改善心功能。 　　[关键词] ST段抬高型心肌梗死；高敏C-反应蛋白；内皮素-1；通心络胶囊 　　[中图分类号] R542.2+2[文献标识码] B [文章编号] 1673-9701???2011）27-85-02 　　 　　Effects of Tongxinluo Capsules on hs-CRP and ET-1 in the Treatment of Acute ST-segment Elevation Acute Myocardial Infarction 　　KUANG YongdongLV Liangdong 　　Cardiovascular Department，Peoples Hospital of Rui’an City in Zhejiang Province，Rui’an 325200，China 　　 　　[Abstract] Objective To investigate the effects of Tongxinluo Capsules on hs-CRP and ET-1 in the treatment of acute ST-segment elevation acute myocardial infarction（STEMI）. Methods All 110 cases with STEMI were randomly divided into study group（60 cases） and control group（50 cases）. Control group was treated by conventional method，study group added Tongxinluo Capsules for treating on the base of control group. Compared the levels of hs-CRP，ET-1 and cardiac function in two group before and after treatment. Results After treatment the decrease levels of hs-CRP and ET-1 in study group were more observably than control group（P＜0.05 or P＜0.01），the rise levels of LVEF and the reduction level of LVEDD and LVESD were more observably than control group（P＜0.05）. Conclusion Tongxinluo Capsules restrain the inflammation of vascular local inflammation of STEMI，improve the Vascular endothelial cells function，reduce the levels of hs-CRP and ET-1，stabilize coronary plaque rapture，improve cardiac function. 　　[Key words] STEMI；hs-CRP；ET-1；Tongxinluo capsules 　　 　　急性ST段抬高型心肌梗死（acute ST-segment elevation acute myocardial infarction，STEMI）是由于冠状动脉斑块破裂形成血栓造成冠状动脉急性完全闭塞，血流中断导致局部心肌透壁性缺血坏死，心电图表现为ST段抬高。冠状动脉血管内皮细胞损伤和冠状动脉斑块炎症反应是主要的危险因素，高敏C-反应蛋白（hs-CRP）