Administration of tetrahydrobiopterin (BH4) improves the microcirculation and outcome in an ovine model of septic sh书籍.pdfVIP

Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock Xinrong He, MD; Fuhong Su, MD, PhD; Dimitrios Velissaris, MD; Diamantino Ribeiro Salgado, MD; Dalton de Souza Barros, MD; Sophie Lorent, PharmD; Fabio Silvio Taccone, MD; Jean-Louis Vincent, MD, PhD, FCCM; Daniel De Backer, MD, PhD Objective: Supplementation with tetrahydrobiopterin, a nitric oxide prevented the decreases in cardiac index and mean arterial pres- synthase cofactor, may reduce microvascular endothelial dysfunction