酚麻美敏片预防干扰素α治疗肾癌术后患者所致流感样症状临床观察.docVIP

酚麻美敏片预防干扰素α治疗肾癌术后患者所致流感样症状临床观察 　　[摘要] 目的 探讨酚麻美敏片对于肾癌术后患者应用干扰素治疗后出现的流感样症状有无预防作用。 方法 2010年10月～2013年4月共有76例肾癌患者于北京积水潭医院行肾癌根治术，所有患者均于术后1周开始每周3次皮下注射干扰素α治疗。剂量为第1周每次3 MU，第2周每次6 MU，如患者可以耐受，则维持每次6 MU注射至术后12周。如患者无法耐受，则降至3 MU甚至停药。患者被随机分为两组，每组各38例，实验组在每次注射干扰素α后半小时开始每6小时服用酚麻美敏片1片，24 h后停药。对照组单独使用干扰素α治疗。比较两组患者在首剂及加量使用干扰素后24 h内的发热及其他流感样症状情况。 结果 首剂使用干扰素后，实验组患者发热比率为13.2%，而对照组为81.6%，差异有高度统计学意义（P 0.05）。对照组中有4例患者无法耐受干扰素带来的严重不适，拒绝加量治疗。而实验组所有患者均参与加量治疗。干扰素加量治疗后实验组发热比率为21.1%，而对照组为85.3%（P 0.01）。而其他流感样症状两组比较差异均有统计学意义（均P 0.05）。治疗后对照组又有4例患者因超高热而不得不降为每次3 MU治疗。相比之下，实验组无患者出现无法耐受而减量的情况。 结论 酚麻美敏片对于预防干扰素α治疗肾癌术后患者所致流感样症状有明显的效果，并且可以显著提高患者的治疗顺应性。 　　[关键词] 酚麻美敏片；干扰素α；肾癌；流感样症状 　　[中图分类号] R737.11 [文献标识码] A [文章编号] 1673-7210（2014）10（a）-0031-04 　　Clinical observation of Paracetamol preventing cold-like symptoms caused by α-interferon in the treatment of renal carcinoma after radical nephrectomy 　　XU Xiao MAN Libo▲ HUANG Guanglin LI Guizhong LIU Ning 　　Department of Urology， Beijing Jishuitan Hospital， Beijing 100096， China 　　[Abstract] Objective To explore whether Paracetamol can prevent cold-like symptoms caused by α-interferon in the treatment of renal carcinoma after radical nephrectomy. Methods From October 2010 to April 2013， 76 renal carcinoma patients who underwent nephrectomy in Beijing Jishuitan Hospital were treated by α-interferon 3 times per week from the first week after operation. 3 million units each time for the first week， and 6 million units for the second week were given to every patient， if the patient could tolerate， the dose would be maintained until the 12th week after operation， otherwise， the dose would be reduced to 3 million units or even withdraw. All the patients were randomized into 2 groups. There were 38 cases in each group. In the treatment group， the patients were treated by α-interferon injection plus Paracetamol 1 pill every 6 hours until 24 hours later， and α-interferon injection alone in the control group. Results After the first time of α-interferon injection， p