统计遗传学姜永帅人类数量遗传分析2.pptx

人类数量遗传学基础;四、 Risch 亲属复发风险模型;define the random variable Xi to be 1 if individual 1 is affected, and 0 if unaffected; similarly,define X2 for a related individual 2 of type R. If the Hardy-Weinberg law is assumed to hold, the population prevalence is given by Define KR = E(X2 ︱X1 =1) to be the recurrence risk for a type R relative of an affected individual. ;the probability that a proband and type R relative are both affected is K x KR = E(X1X2) = Cov(Xl，X2)+ K2. Thus, KR = K + (1/K)Cov(X1,X2). ; ;Two-Locus Models assume that two unlinked loci are involved in disease susceptibility; again