骨肉瘤患者细胞侵袭相关IL―6IL―12血清水平检测临床意义.docVIP

骨肉瘤患者细胞侵袭相关IL―6IL―12血清水平检测临床意义 　　【摘要】 目的：研究血清IL-6及IL-12水平在骨肉瘤患者与健康体检者之间的差异及临床意义。方法：采用酶联免疫吸附法（ELISA）检测160例骨肉瘤患者及250例健康体检者的外周血血清IL-6及IL-12水平，比较两组间IL-6、IL-12水平的差异及其相关性，探讨血清IL-6及IL-12水平与骨肉瘤发病及进展的关系。结果：骨肉瘤组患者血清IL-6水平明显高于对照组（P0.05）。结论：血清IL-6及IL-12水平在骨肉瘤患者表达异常，两者在骨肉瘤的发生中可能起免疫调节作用，IL-12的低表达可能与骨肉瘤的进展相关。 　　【关键词】 骨肉瘤； 白细胞介素6； 白细胞介素12 　　Clinical Significance of Detection of Cell Invasion Related IL-6 and IL-12 Serum Levels in Osteosarcoma Patients/LU Lu，LIAO Pin-hu，XIE Ke-gong，et al.//Medical Innovation of China，2016，13（20）：001-004 　　【Abstract】 Objective：To explore the difference of serum IL-6 and IL-12 levels between the patients with osteosarcoma and healthy individuals，as well as its clinical signifcance.Method：By ELISA，the concentration of serum IL-6 and IL-12 levels were measured in 160 patients with osteosarcoma（osteosarcoma group） and 250 healthy individuals （controls group）.Differences between serum IL-6 and IL-12 levels were compared and analyzed its correlation.The relationship between serum IL-6 and IL-12 levels and the incidence and progression of osteosarcoma were investigated.Result：The levels of serum IL-6 was significantly higher in the osteosarcoma group than in the control group（P0.05）.Conclusion：This study indicates that serum IL-6 and IL-12 levels abnormal expression in osteosarcoma patients. IL-6 and IL-12 may play the role of immunoregulation in the pathogenesis of osteosarcoma，the lower serum IL-12 levels may be associated with development and progression of osteosarcoma. 　　【Key words】 Osteosarcoma； Interleukin-6； Interleukin-12 　　First-author’s address：Affiliated Hospital of Youjiang Medical University for Nationalities，Baise 533000，China 　　doi：10.3969/j.issn.1674-4985.2016.20.001 　　骨肉瘤（Osteosarcoma）来源于原始间充细胞，是最常见的原发性恶性骨肿瘤，多发于青少年及50岁以上的中年人[1-2]。骨肉瘤由恶性成骨细胞分化和产生，其恶性程度较高，治疗困难，且容易发[7-8]。白细胞介素6（interleukin-6，IL-6）的异常表达与肿瘤的发病、侵袭转移相关，并与肿瘤的诊断、预后及治疗相关联[9-11]。白细胞介素12 　　（interleukin-12，IL-12）是一种具有多种生物活性和免疫调节功能的异戊二聚体细胞因子，由抗原提呈细胞、树突细胞、巨噬细胞或B细胞产生[12]。研究证实，IL