首发精神分裂症外周血BDNF与认知功能相关研究.docVIP

首发精神分裂症外周血BDNF与认知功能相关研究 　　[摘要] 目的 对首发精神分裂症外周血BDNF水平与认知功能间相关性行观察与研究。 方法 随机选取2015年5～9月期间我院收治的首发精神分裂症患者150例为治疗组，并选择同期正常人群150例为对照组，均用ELISA测定患者外周血BDNF水平，并比较两组PANSS、CPT与WCST得分。 结果 与对照组相比，治疗组WCST总应答数、WCST持续错误数、WCST随机错误数均较高（P0.05），WCST正确反应数、WCST完成分类数较低（P0.05），差异具有统计学意义；患者外周血BDNF与WCST随机错误数、持续性错误和总应答数呈明显负相关，CPT指标、完成分类数与BDNF呈明显正相关（P0.05）。 结论 对于首发精神分裂症患者来说，具有执行功能受损与血清BDNF下降情况，患者认知功能与外周血血清BDNF水平呈现明显的正相关。 　　[关键词] 首发精神分裂症；外周血；认知功能；BDNF；执行功能；正相关 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1673-9701（2016）07-0008-04 　　[Abstract] Objective To observe and research on the correlation between peripheral blood BDNF level and cognitive function of patients with first-episode schizophrenia. Methods A total of 150 first-episode schizophrenia patients who were admitted and treated in our hospital from May to September 2015 were randomly selected as the treatment group and 150 normal people during the same period were selected as the control group. Peripheral blood BDNF level of the two groups was tested with ELISA and scores of PANSS， CPT and WCST were compared. Results There were significant differences of WCST responses， persistent errors，WCST random errors， WCST correct response， complete classification number compared with control group （P0.05）， which showed statistical significance； there was significant negative correlation between peripheral blood BNDP level and WCST random errors， persistent errors and total responses； there was significant positive correlation between CPT parameters， correct complete classification number and the BDNF level（P0.05）. Conclusion For patients with first-episode schizophrenia， the executive function is damaged and blood BDNP decreases. The cognitive function and peripheral blood BDNP level shows significant positive correlation. 　　[Key words] First-episode schizophrenia； Peripheral blood； Cognitive function； BDNP； Executive function； Positive correlation 　　精神分裂症的病因至今也未能明确，该疾病好发于青壮年群体，患者常存在感知、思维、情感、意志行为等障碍，以及不协调的精神活动，属于严重、病程迁延的精神疾病之一，全球罹患该病的人口数量较多，属于人类可罹患的最严重