翻译沃森和克里克于1953年发表在《科学杂志》关于DNA双螺旋模型的论文.docVIP

分子生物学作业：翻译沃森和克里克于1953年发表在《科学杂志》上的关于DNA双螺旋模型的论文 Nature 科学杂志 Equipment,and to Dr. G. E. R. Deacon and the captain and officers of R.R.S.Discovery II for their part,in making the observations. Molecular structure of nucleic acids 核酸分子结构 A structure for Deoxyribose nucleic acid 脱氧核糖核酸的结构 We wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A). This structure has novel features which are of considerable biological interest. 我们希望去提出一种结构是刺激性的脱氧核糖核酸即DNA。这个结构有一些新的特征对于生物学有很多重要的意义。 A structure for nucleic acid has already been proposed by Pauling and Corey2. 鲍林和科瑞提出了核酸的结构。 they kindly made their manuscript available to us in advance of publication. 在他们出版前，他们爽快的将对他们有用的手稿给我们。 Their model consists of three intertwined chains,with the phosphates near the fibre axis,and the bases on the outside. 他们提出的模型由三个缠绕的链组成，以磷酸盐靠近纤维轴线并且盘绕在外部。 In our opinion,this structure is unsatisfactory for two reasons: 以我们的观点，这个架构是不满意的两个原因 (1)We believe that the material which gives the X-ray diagrams is the salt,not the free acid,without the acidic hydrogen atoms it is not clear what forces would hold the structure together,especially as the negatively charged phosphates near the axis will repel each other.(2)some of the wan der waals distances appear to be too small. （1）我们相信这种材料在X射线钠盐环境下，不是游离的酸，没有酸性氢原子，不清楚是什么力量将它们的结构结合在一起，尤其是靠近轴的负的带负电的磷酸盐互相排斥的现象。 （2）一些范德华力距离很小。 Another three-chain structure has also been suggested by Frase (in the press).IN his model the phosphates are on the outside and the bases on the inside ,linked together by hydrogen bonds. This structure as described is rather ill-defined,and for this reason we shall not comment on it. 另一个三条链结构被费斯提出并即将出版。在他的提出的模型中磷酸盐在外部的与在内部的通过氧氢键共同连接组成。这个机构也被描述为有些不明确，因为这个原因我们没有对它提出意见。 We wish to put forward a radically different structure for the salt of deoxyribose nucleic acid.This structure has two helical chains each coiled round the same axis(see diagram). 我们希望提出了一个结构与脱氧核糖核酸结构本质不同的结构。这个结构有两个螺旋形的链每一个盘绕着相同的轴（看图表） We have made the us