冠心病患者血浆脂联素与白介素1β变化及相关性研究.docVIP

冠心病患者血浆脂联素与白介素1β变化及相关性研究 　　[摘要] 目的:探讨冠心病患者血浆脂联素和白介素-1β(IL-1β)水平的变化及其关系。方法:冠心病患者60例,其中,稳定型心绞痛(SAP)30例,不稳定型心绞痛(UA)30例;选择年龄、性别、体重与其匹配的30例作为健康对照。用酶联免疫吸附(ELISA)法测定两组血浆脂联素及IL-1β浓度,分析两者在冠心病患者血浆中的变化及相互关系。结果:SAP组和UA组脂联素水平均显著低于对照组(均P0.001);UA组血清IL-1β明显高于对照组(P0.001)。UA组及SAP组血清脂联素与IL-1β呈负相关(r1=-0.27,P0.01;r2=-0.31,P0.01)。结论:脂联素水平降低和IL-1β水平升高可能是冠心病发生及发展的重要因素;IL-1β的改变与脂联素水平呈负相关,提示脂联素的代谢可能影响IL-1β的表达。 　　[关键词] 冠心病;脂联素;白介素-1β 　　[中图分类号] R541.4 [文献标识码]B[文章编号]1673-7210(2010)04(a)-033-02 　　 　　Relationship between adiponectin and IL-1β expression in patients with coronary heart disease 　　QU Wei, XIE Yutong 　　(Department of Cardiology, the Fourth Peoples Hospital of Shenyang City, Shenyang 110031, China) 　　[Abstract] Objective: To investigate the changes of serum adiponectin and IL-1β, and evaluate the relationship between adiponectin and IL-1β in patients with coronary heart disease. Methods: 60 patients with coronary heart disease were enrolled [30 cases of unstable angina (UA) and 30 cases of stable angina (SAP)]. 30 healthy people matched in age, sex and body mass served as control. Serum adiponetin and IL-1β was measured by enzyme-labeled immunosorbent assay (ELISA). Results: The serum level of adiponectin in UA and SAP group was lower than that of control group (both P0.001). The concentration of IL-1β in patients with UA was higher than that of control group (P0.001). The concentration of serum adiponectin of UA and SAP group was negatively correlated with that of IL-1β (r1=-0.27, P0.01; r2=-0.31, P0.01). Conclusion: Adiponectin and IL-1β may play a role in the pathogenesis of coronary artery disease. IL-1β is negatively correlated with adiponectin, suggesting that adiponectin may influence the expression of IL-1β. 　　[Key words] Coronary heart disease; Adiponectin; IL-1β 　　 　　近年研究发现,脂肪组织不仅是一个能量储存器官,而且也是一个???有内分泌功能的组织,它可以分泌多种调控机体代谢和能量平衡的活性因子,包括瘦素(leptin)、肿瘤坏死因子-α(TNF-α)、纤溶酶原激活物抑制剂-1(PAI-1)、抵抗素(resistin)、白介素-6(IL-6)、脂联素(adiponectin,APN)等,其中APN是脂肪组织特异性分泌的具有类似胶原结构的蛋白,在肥胖、胰岛素