优泌乐50-简约强化课件.ppt

简约强化, 提高胰岛素治疗患者的达标率;大 纲;;根据2010年指南更新的标准（7%）,仍有72.84%的人群HbA1c不达标;如何解决？;胰岛素治疗的糖尿病患者依从性很差;大 纲;患者依从性差导致HbA1c控制不佳;依从性差的患者HbA1c控制显著劣于依从性好的患者;依从性差的患者糖尿病并发症发生率高;依从性差患者总体幸福感量表得分较差;依从性差的患者死亡风险升高3.2倍;大 纲;给药次数越少患者依从性越高;由此可见：控制血糖应加强对依从性的关注;基础+餐时胰岛素治疗方案2种注射装置，4次注射/天;强化的基础/餐时胰岛素治疗方案;大 纲;PPT VS BBT策略;基础/餐时胰岛素的混合比例为 1：1，与胰岛素皮下持续输注(CSII)或内源性胰岛素分泌相似 每日三餐前注射，与速效胰岛素相似 仅用一种胰岛素就能同时补充基础和餐时胰岛素;Rosenstock J, et al. Diabetes Care 2008; 31:20-25 ;Rosenstock J, et al. Diabetes Care 2008; 31:20-25 ;Rosenstock J, et al. Diabetes Care 2008; 31:20-25 ;Data on file, 2006 Eli Lilly Company;Rosenstock J, et al. Diabetes Care 2008; 31:20-25 ;Rosenstock J, et al. Diabetes Care 2008; 31:20-25 ;Data derived from Rosenstock J, et al. Diabetes Care 2008; 31:20-25 ;Data derived from Rosenstock J, et al. Diabetes Care 2008; 31:20-25 ;Rosenstock J, et al. Diabetes Care 2008; 31:20-25 ;;PRIME研究;Jain et al. Diabetes Obes Metab 2010;12(11):967-75;G±L,：单用甘精胰岛素或增加≤3次优泌乐 PP：优泌乐50;;BMI, body mass index; G±L, glargine once daily alone or plus ≤3 mealtime lispro; PP, premix progression (insulin lispro mix 50/50 once up to thrice daily); SD , standard deviation Data are mean ± SD or n (%);A1C, hemoglobin A1C; FBG, fasting blood glucose; G±L, glargine once daily alone or plus ≤3 mealtime lispro; LSM, least-squares mean; Met, metformin; OAMs, oral antihyperglycemic agents; PP, premix progression (insulin lispro mix 50/50 once up to thrice daily); SD, standard deviation; SE, standard error; Sulf, sulfonylurea; TZD, thiazolidinedione Data are mean ± SD or n (%) except for FBG; *p=0.014;Jain et al. Diabetes Obes Metab 2010;12(11):967-75;A1C, hemoglobin A1C; G±L, glargine once daily alone or plus ≤3 mealtime lispro; PP, premix progression (insulin lispro mix 50/50 once up to thrice daily) Data are mean±standard error;血糖测定时点;PP组与G+L组的体重增加相似;Jain et al. Diabetes Obes Metab 2010;12(11):967-75;Jain et al. Diabetes Obes Metab 2010;12(11):967-75;PRIME研究总结;预混人胰岛素不达标患者解决策略优泌乐50 TID vs人胰岛素70/30BID的研究;Schernthaner G et al. Ho