多路径下基因的转录平均水平和噪音强度.docVIP

多路径下基因的转录平均水平与噪音强度 摘要基因表达及其调控是分子生物学的核心问题,是当前生命科学研究的重要分支。作为国际上研究的热门课题,它引起了生物、化学、物理、医学等领域专家的广泛关注。基因转录是基因表达的第一步,也是最为关键的一步。由于RNA观测技术的发展,比如对单个活细胞中RNA合成的实时观测,生物学家们发现基因是以随机的、不连续的、爆发的方式转录的。基因转录的随机性直接导致了RNA与蛋白质的不均匀、不规则分布。近年来,许多科学家对基因表达的随机性产生了浓厚的兴趣,并运用数学方法进行了深入的研究。通过研究，当我们确定了表达式之后，就能更科学地表达基因表达的随机性 本课题的重点是理解微分方程和随机分析的方法，建立随机基因表达的数学模型，得到了由模型参数确定的mRNA或蛋白质数量的均值、噪声、噪声强度、及概率分布函数的解析表达式。 关键词：基因转录，噪音，噪音强度，mRNA Abstract: gene expression and regulation is the core issue of molecular biology, is the most important branch of life science research. As a hot topic of research in the world, it has attracted extensive attention in biology, chemistry, physics, expert medical fields. Gene transcription is the first step of gene expression, but also the most critical step. Due to the development of RNA observation techniques, such as a single live real-time observation synthesis in RNA cells, biologists found that the gene is in a random, discontinuous, burst mode of transcription. Random gene transcription and protein RNA directly leads to the uneven, irregular distribution. In recent years, many scientists of random gene expression had a strong interest in, and studied by using mathematical method. Through the study, when we determine the expression, can more scientific expression of random gene expression The focus of this project is to understand the method of differential equation and stochastic analysis, a stochastic gene expression model, analytical expressions for the mean number of mRNA or protein, noise, noise intensity, and the probability distribution function is determined by the parameters of the model are obtained. Keywords: gene transcription, noise, noise intensity, mRNA 目录 摘要 1 Abstract: 2 1.绪论 4 1.1 生物背景 4 1.2 基因转录过程 5 1.3 关于基因转录噪声的研究 7 2. 多路径下基因的转录平均水平 8 2.1 mRNA的平均表达水平 8 2.2 均值的计算 13 3. 基因转录噪声 15 3.1基因转录噪声强度及影响因素 15 3.2 噪声的计算 15 4.总结 18 参考文献 18 1.绪论 1.1 生物背景 世界上所有的生物,从低等的细菌到人类自身,全部都是由细胞构成。细胞是生命存在的基本结构单位及功能单位。地球上绝大部分的有机生命体是单细胞生物,但人体却是由ICP到lOM多个细胞构成的,这些细胞根据其特征和功能可以划分为200多种不同的类