HCC生物标志物讲解材料.pptVIP

人口学特点 Marrero JA, et al. J Hepatol 2005; 43: 1007–1012 GP73的检测，是免疫印迹方法进行半定量分析 GP73表达随肝病进展而上调 Marrero JA, et al. J Hepatol 2005; 43: 1007–1012 GP73较AFP更好的区别肝硬化和HCC Marrero JA, et al. J Hepatol 2005; 43: 1007–1012 GP73在区别早期HCC和肝硬化方面优于AFP Marrero JA, et al. J Hepatol 2005; 43: 1007–1012 GP73在诊断HCC方面优于AFP Marrero JA, et al. J Hepatol 2005; 43: 1007–1012 肝细胞癌（HCC）生物标志物现状 HCC筛检现状 B超，敏感度65–80%，特异度≥90 % AFP，cut-off设为20 ng/ml敏感度为 60% AFP，敏感度差强人意 Caroline D.M. Witjes，et al. New Insights in Hepatocellular Carcinoma. 2012,1st edition AFP的PPV较不理想 AFP的临床意义有限 Mona Abu El Makarem. Hepat Mon . 2012; 12 (10