右美托咪定硬膜外给药对产妇分娩镇痛产后出血氧化应激的作用的影响.docVIP

右美托咪定硬膜外给药对产妇分娩镇痛产后出血氧化应激的作用的影响 　　[摘要] 目的 分析右美托咪定硬膜外?o药对产妇分娩镇痛产后出血氧化应激作用影响。 方法 选取2015年5月～2017年5月间在本院要求进行硬膜外分娩镇痛产妇360例，依据随机数字表法将产妇分成两组。试验组（180例）镇痛采用右美托咪定结合罗哌卡因，对照组（180例）镇痛只采用罗哌卡因。观察两组产妇分娩前后血清氧化应激相关指标和炎症抑因子水平的变化情况。 结果 分娩后试验组、对照组产妇血清过氧化氢酶（CAT）、谷胱甘肽（GSH）和超氧化物歧化酶（SOD）水平较分娩前下降，血清丙二醛（MDA）和一氧化氮（NO）水平较分娩前上升，但试验组分娩前后对比差异无统计学意义（P0.05），对照组分娩后与分娩前、试验组对比差异均有统计学意义（P0.05），对照组分娩后与分娩前、试验组对比差异均有统计学意义（P0.05）。 结论 右美托咪定硬膜外给药可降低产妇分娩镇痛产后出血的氧化应激损伤，对炎症因子释放有抑制作用。 　　[关键词] 右美托咪定；硬膜外给药；产后出血；氧化应激 　　[中图分类号] R614 [文献标识码] B [文章编号] 1673-9701（2018）01-0104-03 　　Effects of epidural administration of dexmedetomidine on the oxidative stress induced by delivery anagesia of postpartum hemorrhage in puerpera 　　ZHENG Jiangmei ZHOU Huafeng PING Yongmei 　　Department of Anesthesiology， Lishui Women and Childrens Hospital in Zhejiang Province， Lishui 323000， China 　　[Abstract] Objective To analyze the effect of epidural administration of dexmedetomidine on the oxidative stress induced by delivery anagesia of postpartum hemorrhage in puerpera. Methods From May 2015 to May 2017， 360 puerpera who were required to receive epidural administration of delivery analgesia by our hospital were selected. According to the random number table method， the puerpera were divided into two groups. The experimental group（180 cases） was given dexmedetomidine combined with ropivacaine for analgesia； the control group（180 cases） was only given ropivacaine for analgesia； the changes of relevant indices of serum oxidative stress and levels of inflammatory inhibitory factors in the two groups of puerpera before and after delivery were observed. Results The levels of serum catalase（CAT）， glutathione（GSH） and superoxide dismutase（SOD） in the experimental group and the control group after delivery were lower than those before delivery， and the levels of serum malondialdehyde（MDA） and nitric oxide（NO） were higher than those before delivery， but there was no statistically significant difference in the experimental group before and aft