分子生物学杨洋第七章翻译-3.ppt

Molecular biology course Antibiotics inhibit cell division by blocking specific steps in translation—a powerful tool to fight disease Targets of many antibiotics are translational machinery Overview of the events of translation In addition to medical benefits, antibiotics can play important role in research for understanding the function of translational machinery Puromycin (嘌呤霉素) Puromycin (嘌呤霉素) causes polypeptide synthesis to terminate prematurely Use puromycin to explore the translational mechanism: Use puromycin to study the peptidyl transferase reaction and prove that ribosome is