布拉酵母菌对轮状病毒性肠炎治疗的作用的研究.docVIP

布拉酵母菌对轮状病毒性肠炎治疗的作用的研究 　　摘要]目的 探?补充布拉酵母菌治疗儿童轮状病毒性肠炎的临床效果。方法 以2011年9月～2013年9月在厦门市妇幼保健院门诊或住院治疗的6个月～5岁的轮状病毒性肠炎的患儿为研究对象，采用随机数字表法分为实验组和对照组。对照组给予口服补液盐和/或静脉补液、思密达和甘草锌，实验组则在对照组的基础上再给予布拉酵母菌口服。观察比较两组患儿的治疗显效率、总有效率、脱水纠正时间、热退时间及症状改善情况。结果 最终308例患儿纳入本次研究，其中实验组148例，对照组160例。实验组显效率为87.2%，有效率为98.0%，显著高于对照组（61.3%、83.2%），差异均有统计学意义（P0.05）。实验组患儿脱水纠正时间为（1.08±0.51）d，热退时间为（0.77±0.35）d，对照组分别为（2.51±0.84）d和（1.20±0.64）d，差异均有统计学意义（P0.05）。结论 基础治疗联合布拉酵母菌治疗儿童轮状病毒性肠炎，各项症状消除速度更快、腹泻治愈用时短，值得临床应用和推广。 　　[关键词]布拉酵母菌；轮状病毒性肠炎；益生菌；腹泻 　　[中图分类号] R723.11 [文献标识码] A [文章编号] 1674-4721（2016）12（a）-0085-04 　　Effect of Saccharomyces boulardii on children with rotavirus enteritis 　　CHEN Jing-fang1 YANG Xiao-qing2 LIN Bao-hua2 SHEN Tong2 　　1.Department of Pediatrics，Children′s Hospital of Fudan University Xiamen Branch Xiamen Children′s Hospital，Xiamen 361006，China；2.Department of Pediatrics，Maternal and Children Health Care Hospital of Xiamen，Xiamen 361003，China 　　[Abstract]Objective To investigate the effect of Saccharomyces boulardii on children with rotavirus enteritis.Methods From September 2011 to September 2013，a randomized case controlled trial was performed in Maternal and Children Health Care Hospital of Xiamen.All of the children were aged from 6 months to 5 years and diagnosed as rotavirus enteritis.Patients were randomly divided into experimental group and control group.Oral rehydration salts and/or intravenous rehydration，Dioctahedral Smectite and licorice zinc were given to the control group routinely；on the basis of the treatment of the control group，Saccharomyces boulardii was given to the experimental group additionally.Dehydration correction time，heat recovery time and frequency of stool were detected in two groups.Results A total of 308 children were enrolled in this study at last，148 cases in the experimental group，160 cases in the control group.The effective rate was 87.2% in the experimental group，whereas 61.3% in the control group，and there was significant difference between the two groups （P