利培酮的有效代谢产物9-羟利培酮的血浆浓度的测定及其临床意义-沙维伟.pdfVIP

2004 8 6 # 36 # Journal of Clinical M edicine in Prac ice 9O 沙维伟, 刘进文, 周朝昀, 张晓斌 ( , , 225003) : 9O, 56 345 mg , 4 HP L C 9O 4 ( PA N SS) 9O 345 mg 9O, 9O4 9O PAN SS 9O , 9O, : ; 9O; ; : R 74913 : A : 1672O2353( 2004) 06O0036O03 PLASMA 9OHYDROXYRISPRRIDONE LEVEL OF RISPERIDONEcS ACTIVE METABOLITE AND ITS CLINICAL SIGNIFICANCE SHA WeiOwei, LIU JinOwen, ZHOU Ch oOyun, ZHANG Xi oObin ( Department of Psychiatry, Af f iliated Yangz hou Wutaishan H osp ita of Medical College of Yangz hou University , Yangz hou, iangsu 22500 3) ABSTRACT: Objective T o observe he rela ionship among oral dose, plasma drug level and he clinical signif icance of risperidone. Methods T he s udy w as conduc ed in 56 pa ien s w i h schizophrenia. T hey were divided o receive 3 m g, 4 mg or 5 mg risperidone for 4 w eeks. T he plasma drug levels of 9Ohydroxy risperidone w ere measured by H PLC me hod a he end of Week 4. T he PAN SS w ere evalua ed a Week 1 and 4. Results T he dif ference of oral dose of risperidone and plasma levels of 9Ohydrox yrisperidone were signif ican be ween male and f emale pa ien s. T he plasma levels of 9Ohy drox yrisperidone were signif ican ly diff eren among he 3 mg, 4 mg and 5 mg group. T he oral dose of risperidone w as signif ican posi ive correla ed w i h he plasma levels of 9O hydrox yrisperidone. T he plasma level of 9Ohydroxyrisperidone w as no co