基于微胶囊的生物传感器教学幻灯片.pptVIP

基于微胶囊的光学生物传感器Microcapsules as optical biosensors;Examples of this concept : fluorescent microspheres/capsules, hollow fiber membranes encapsulating sensing chemistry, and polymeric slabs doped with fluorescent reagents. the target species are able to freely diffuse into the container, while permanently compartmentalizing the sensing reagents;Encapsulation within polyelectrolyte multilayer capsules ;layer-by-layer (LbL) nanoscale self-assembly process allows for an even wider assortment of candidate materials.;Three principal methods: Precipitation, adsorption/absorption, diffusion ;1. Diffusion;Examples： ;3. Precipitation;Biosensors using PEM capsules;Examples： ;Difficult challenges ;Further work;[1] Mike McShane, Dustin Ritter, “Microcapsules as optical biosensors”, Journal of Materials Chemistry, 20(2010)8189–8193 [2] Aimin Yu, Ian R. Gentle, Gao Qing (Max) Lu, “Biocompatible polypeptide microcapsules via templating mesoporous silica spheres”, Journal of Colloid and Interface Science 333 (2009) 341–34 [3] Tania Saxla, Faaizah Khan, Daniel R. Matthews, Zheng-Liang Zhi, Olaf Rolinski, Simon Ameer-Beg, John Pickup, “Fluorescence lifetime spectroscopy and imaging of nano-engineered glucose sensor microcapsules based on glucose/galactose-binding protein”, Biosensors and Bioelectronics, 24 (2009) 3229–3234 [4] C.E. Mora-Huertas, H. Fessi, A. Elaissari, “Polymer-based nanocapsules for drug delivery”, International Journal of Pharmaceutics 385 (2010) 113–142;Thank you!