脓毒症30-2016新定义新治疗.pptVIP

PICS（持续炎症、免疫抑制和代谢综合征） New syndrome for individuals who survive the initial sepsis event but become chronically critically ill—the “persistent inflammation-immunosuppression and catabolism syndrome” (PICS) .  PICS is defined as ongoing inflammation, manageable organ failure, ongoing protein catabolism, and poor nutrition, leading to cachexia, poor wound healing, and immunosuppression with increased susceptibility to secondary infections. Model of persistent inflammation-immunosuppression and catabolism syndrome (PICS). Role of myeloid-derived suppressor cells (MDSCs) in severe sepsis/s