系统生物最新进展与药物设计-Nature.docVIP

PAGE \* MERGEFORMAT 2 Support information Computational insights into the G-protein biased activation and inactivation mechanism of μ opioid receptor Jianxin CHENGa,b, Tao CHENGa, Weihua LIa, Guixia LIUa, Weiliang ZHUb, Yun TANGa,* a Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China b Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China * Corresponding author, Tel: +86-21 E-mail: HYPERLI