三类中药制剂对急性肾衰影响的比较-中国农学通报.PDF

中国农学通报 2013,29(32):54-57 Chinese Agricultural Science Bulletin 三类中药制剂对急性肾衰影响的比较 王 华，周孝琼，李 焰，陈小红 （龙岩学院生命科学学院，福建龙岩364000） 摘 要：为了研究瘟清注射液、香丹注射液和术苓注射液对内毒素所致急性肾衰家兔的防治作用。将40 只健康哈尔滨白兔随机分为阴性对照组、模型组、瘟清组、香丹组和术苓组，每组8 只。模型组和各防治 组家兔一次性静脉注射大肠杆菌O111B4 内毒素生理盐水溶液；三防治组家兔在注射内毒素后立即静脉 注射相应的中药注射液；阴性对照组静注生理盐水。各组家兔静注液体的总量相等。注射内毒素（或生 理盐水）1 h 后开始通过膀胱瘘管收集尿液，每小时收集1 次，共收集6 h 。末次收集尿液后心脏采血。对 各组家兔的肾功能指标进行动态测定。结果显示：模型组家兔发生了急性肾功能衰竭。和模型组比较， 瘟清组家兔的肌酐、尿素氮排出量显著或极显著增加(P0.05 ，P0.01) ，肾衰指数和钠排泄分数显著或极 显著降低(P0.05 ，P0.01) ，内生性肌酐清除率显著或极显著升高(P0.05 ，P0.01) 。除肾衰指数和钠排 泄分数之外，香丹组家兔绝大多数肾功能指标的变化趋势与瘟清组相似。试验结果表明：瘟清注射液对 急性肾衰具有确实的防治作用；香丹注射液亦有良好的防治急性肾衰作用；术苓组家兔肾功能衰竭状况 并未得到根本好转。 关键词：急性肾功能衰竭；内毒素；瘟清注射液；香丹注射液；术苓注射液 中图分类号：S853.23 文献标志码：A 论文编号：2013-1960 Comparative on Effects of three Traditional Chinese Medicine Preparations on Acute Renal Failure Wang Hua, Zhou Xiaoqiong, Li Yan, Chen Xiaohong (CollegeofLifeSciences,LongyanUniversity, Longyan Fujian 364000) Abstract: The preventive and therapeutic effects of three traditional Chinese medicine preparations, i.e. Wenqing (WQ), Xiangdan (XD) and Zhuling (ZL) injections, on endotoxin (ET)-induced acute renal failure (ARF) were investigated in Harbin white rabbit. Forty rabbits were randomly divided into five groups, namely negative control, model, WQ, XD and ZL, eight for each group. The rabbits, except those of negative control group, were given an intravenous injection of E. coli O111B4 ET solution. After the injection of ET, the rabbits of WQ, XD and ZL groups were immediately injected corresponding preparations. The negative control rabbits were given an intravenous injection of normal saline (NS). Liquid inject