碳青霉烯类抗菌药物比较与选用.pdfVIP

药物与临床 Drugs and Clinic 碳青霉烯类抗菌药物的比较与选用 1 1 1 2 3* 王乐 ，张洪峰 ，陈晴 ，王辉 ，陈瑞玲 1.邯郸市中心医院药剂科，河北 邯郸 056001；2.邯郸市中心医院老年病科，河北 邯郸 056001；3.首都医科大学附属北京 天坛医院药剂科，北京 100050 摘要：目的：对目前国内外已上市的碳青霉烯类抗菌药物进行比较，促进临床合理用药。方法：查阅近年相关文献，对国内 外已上市的碳青霉烯类抗菌药物的研发史、化学构效、临床应用等方面做对比分析。结果：碳青霉烯类药物是临床治疗重症 感染非常重要的一类抗菌药物，每种药物的结构和药理作用特点、疗效和安全性不尽相同。结论：临床选用碳青霉烯类抗菌 药物时，要结合每一种药物的药理作用特点，并结合患者的个体情况，合理的选用碳青霉烯类药物，最大程度地保证药物临 床治疗的有效性和安全性。 关键词：碳青霉烯类；研发史；化学构效；药理作用 [中图分类号]R969 [文献标识码]A [文章编号]1672-2809(2011)08-0032-06 Comparison and Selection of Carbapenem Antibiotics 1 1 1 2 3* WANG Le , ZHANG Hong-feng , CHEN Qing ，WANG Hui ，CHEN Rui-ling 1. Department of Pharmacy, Central Hospital of Handan, Handan 056001; 2. Department of Geriatrics, Central Hospital of Handan, Handan 056001; 3. Department of Pharmacy, Beij ing Tiantan Hospital Affiliated to Capital Medical University, Beij ing 100050 Abstract: Obj ective: To make a comparison on post-marketing carbapenems at home and abroad for promoting rational drug use. Methods: The relative literatures in recent years were collected. The following aspects were analyzed and summarized: research and development history, chemical structure-activity and other characteristics in clinical use of carbapenems. Result: Carbapenem antibiotics were very important in severe infection treatment. The structure, pharmacological characteristics, efficacy and safety of different carbapenems antibiotics were also different. Conclusion: The pharmacological characteristics of each type of carbapenem antibiotics and each individual condition should be considered when selecting carbapenem antibiotics to ensure the maximum degree of effectiveness and safety. Key words: Carbapenems; Research and development history; Chemical structure-activity ；Comparison in clinical use 碳