痛觉产生基础理论知识.pptVIP

Fig. 1 王韵 Fig.2 王韵 Fig.4 王韵 Fig.5 pain Mechanical, Chemical-electrical -chemical-electrical SP glutamate 王韵 王韵 Fig.6 Descending inhibition Perception distinguish 王韵 王韵 Pain has two opposite effects on our life Pain teaches us to avoid harmful situations; Elicits withdrawal reflexes from noxious stimuli Exhorts us to rest an injured part of our body Without pain will be a short life Good Vital pain can be persistent or chronic such as inflammatory pain, neuropathic pain, psychogenic pain and cancer pain, it appears to serve no useful purpose,only makes patients miserable Get more pain will be a misery life, too Bad evil 王韵 Cancer associated pain As advances in cancer detection and therapy are extending the life expectancy of cancer patients, there is an increasing focus on improving patients’ quality of life Pain is the first sign of cancer of many patients, 30-50% of all cancer patients will experience moderate to severe pain Cancer can cause pain at any time during the course of the disease, but the frequency and intensity of pain tend to increase during the advanced stages 75-95% of patients with metastatic or advanced-stage, cancer will experience significant amounts of cancer induced pain The current treatment for cancer pain showing many unwanted side effect, 45% of cancer patients have inadequate and undermanaged pain control 王韵 王韵 Peripheral mechanism of pain: second messengers PKC-independent pathway 王韵 PLCβ BK2-receptor PIP2 IP3 DG [Ca2+]i↑ PKC bradykinin Gq VR1 ? PKC-dependent pathway Peripheral mechanism of pain: second messengers 王韵 Peripheral mechanism of pain: lipids G-protein-coupled receptor Arachidonic acid cAMP↑ PKA TTX-R Na+ channels pain PEG2 AC aspirin opiates ? 王韵 Peripheral mechanism of pain: a summary for second messengers 王韵 cool 10-28℃ CMR1 heat 45℃ VR1 53℃ VRL-1 pressure DEG/ENaC