二次电切对表浅性膀胱癌治疗的Meta分析-泌尿外科专业论文.docxVIP

TUR 的病人术后肿瘤复发率明显低于传统行 TUR-BT 的病人；（2）3 个试验可 以提取 Second TUR 对表浅性膀胱癌治疗干预后疾病进展例数的具体数值，统计 分析合并数据后 OR＝0.25，95%CI(0.12，0.5)，有显著统计学差异，即常规进行 Second TUR 的病人术后疾病进展率明显低于传统行 TUR-BT 的病人。 结论 根据以上分析统计结果，二次 TUR 能有效的降低表浅性膀胱癌术后肿瘤复发 率和疾病进展率。但由于纳入研究数量少，且高质量的文献不多，存在选择偏倚、 实施偏倚以及发表偏倚的可能性，很可能影响结果的可靠性，故应谨慎看待以上 结论，期待更多高质量的随机对照试验提供更可靠的证据。 关键词 二次 TUR；二次电切；表浅性膀胱癌；非肌层浸润性膀胱癌;；系统评价； Meta 分析 A Meta-analysis of Second Transurethral Resection for Treatment of Superficial Bladd Cancer Abstract Objective: To evaluate the efficacy and safety for second TUR ,compared with traditional TUR-BT,on recurrence rate and progression rate.To provide the best evidence for clinical treatment decisions and future research. Methods: Searches were applied to following electronic database:Medline; Pubmed/Medline database(1980.1-2010.12)、OVID（1980.1-2010.12）、 EMBASE(1980.1-2010.12)、 CBM(1980.1-2010.12）、CNKI(1980.1-2010.12)、 CEBM\CCD、Cochrane Liberaray. Meanwhile, Hand search was applied in recent Chinese J Urol、Journal of Clinial Urology and other four journals. Randomized controlled trials(RCTs) and Controlled clinial trial comparing Second TUR with No second TUR for superficial bladder cancer were included. Controlled trial should be used without limiting language or only used blinding participant. Date were extracted independently by two Reviewer.The methodological quality of trails was assessed by the jada-Score. Trials were assessed for quality according to the randomization，allocation concealment，blinding，loss to follow- up and baseline，and graded their methodological quality according to the Cochrane handbook for systematic reviews of interventions.Meta- analysis was performed using Revman5.0 software provided by the Cochlane collaboration. For dichotomous data,results were expressed as Odds Ratio(OR) and 95% confidence internals(CI). After heterogeneity test，data without heterogeneity could be pooled using fixed effect model， and those with heterogeneity could be solved by randomized effect model.Oweing to modera