讲课—抗抑郁药整理版.pptVIP

* * The “cleaner” the drug, the better the side effect profile. Agents that have greater affinities to multiple receptors will, by definition, run a greater risk of creating unwanted side effects. This slide shows the relationship between neurotransmitter affinity, receptor activity and clinical side effects. * * * * Both pharmacodynamic and pharmacokinetic issues are implicated in the case of discontinuation symptoms. TCAs, MAOIs, paroxetine and venlafaxine have a higher risk for this syndrome while citalopram, fluoxetine and nefazodone have the lowest risk associated with this syndrome. The