肿瘤分子生物学检验.pptVIP

* 一、 乳腺癌 女性发病率高，5%-10%为家族性。 90%家族性乳腺癌涉及BRCA1和BRCA2基因突变。 BRCA1突变可发生在所有细胞，若发生在精子或卵子则可以传给下一代。 其他涉及基因：p53、PTEN、c-myc、端粒酶等。 论文导读: A strong candidate for the breast and ovarian卵巢 cancer susceptibility gene BRCA1 /cgi/rapidpdf/266/5182/66.pdf * BRCA1 BRCA1 (breast cancer 1, early onset早发) is a human tumor suppressor gene肿瘤抑制基因, which produces a protein, called breast cancer type 1 susceptibility易感性 protein. It is found in the cells of breast and other tissue, where it helps repair damaged DNA, and destroy the cell when DNA can‘t be repaired. If BRCA1 itself is damaged, the damaged DNA can let the