乙胺嘧啶药物的多晶型及性质研究.pdfVIP

Advances in Analytical Chemistry 分析化学进展, 2018, 8(3), 112-123 Published Online August 2018 in Hans. /journal/aac /10.12677/aac.2018.83014 Study on the Polymorph and Properties of Pyrimethamine * Jing Lan, Xiaozhen Feng , Guocheng Han School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin Guangxi th th nd Received: Jul. 7 , 2018; accepted: Jul. 26 , 2018; published: Aug. 2 , 2018 Abstract In this paper, polymorph of pyrimethamine was studied by using the sublimation and recrystalli- zation of the drug to prepare form A, B and C three types of crystal, which were characterized by SEM, XRD and IR spectra. At the same time, the tablets of three crystals were prepared according to “Chinese Pharmacopoeia” 2015 version for testing, and focused on whether the tablets of the dissolution profile similarity. Form A converted to Form B after sublimation at 280˚C, Form B re- crystallized in ethanol to give crystal Form C. The solubility results show that A crystalline has slightly hygroscopic; B polymorph has hygroscopic. The prepared tablets of Form A and Form B pyrimethamine about content, content uniformity, dissolution test results are in line with the scope of the 2015 edition of Chinese Pharmacopoeia standards. The dissolution curves of Form A and Form B pyrimethamine are similar to each other. Keywords Pyrimethamine, Drug Polycrystalline, Quality, Dissolution 乙胺嘧啶药物的多晶型及性质研究 * 兰 晶，冯小珍，韩国成 桂林电子科技大学生命与环境科学学院，广西 桂林 收稿日期：2018年7月7 日；录用日期：2018年7月26 日；发布日期：2018年8月2 日 摘 要 采用升华法和重结晶法制备乙胺嘧啶药物的A 、B、C三种晶型，通过扫描电镜，XRD和红外光谱对三种