接种方式.docxVIP

1 Intervention background: Hepatitis B virus (HBV) infection, which was highly prevalent in China, is a main cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma.1 Beasley RP, Hwang LY, Lin CC. Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22,707 men in Taiwan. Lancet 1981;2:1129–33. As HBV infection usually occurs during infancy or early childhood when it is most likely to become chronic, the vaccination of infants beginning at birth is the key strategy in preventing chronic HBV infection. In China, the hepatitis B vaccine (HepB) was first used in 1987