甲基苯丙胺的急性和慢性作用机理的研究进展-生命科学.PDF

第26卷第9期 生命科学 Vol. 26, No. 9 2014年9月 Chinese Bulletin of Life Sciences Sep., 2014 DOI: 10.13376/j.cbls/2014140 文章编号：1004-0374(2014)09-0974-05 甲基苯丙胺的急性和慢性作用机理的研究进展 卫星辰，周小爽，徐嘉珂，白　洁* ( 昆明理工大学生命科学与技术学院，昆明 650500) 摘　要 ：甲基苯丙胺是一种被广泛使用的神经兴奋剂，它可以使人兴奋，产生欣快感并引起幻觉。这主要 5- 5- 是因为脑内的多巴胺和 羟色胺急剧大量增加所致。长期使用甲基苯丙胺，会对多巴胺和 羟色胺神经 末梢产生持续性的损伤。甲基苯丙胺毒性机理包括兴奋性毒性、线粒体损伤、氧化应激、代谢改变以及炎 症反应等，这些均会造成神经末梢损伤。综述了甲基苯丙胺造成神经末梢急性和慢性损伤的机制。 关键词：甲基苯丙胺；多巴胺；5- 羟色胺；兴奋性毒性 中图分类号：Q42 ；R595.4 ；R964 文献标志码： A Progress in mechanisms on actue and chronic toxicities of methamphetamine WEI Xing-Chen, ZHOU Xiao-Shuang, XU Jia-Ke, BAI Jie* Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China ( ) Abstract: Methamphetamine is a widely used psychostimulant drug, which makes user feel excitement, euphoria, and hallucination. These symptoms are related with acute increases of dopamine and serotonin. Long term use of methamphetamine results in damage to dopamine and serotonin nerve terminal. Methamphetmine toxicity mechanisms include excitotoxicity, mitochondria damage and oxidative stress, metabolic changes, inflammatory reaction, which are related with nerve terminals. Subsequent to these acute effects, methamphetamine produces persistent damage. This paper reviews damage mechanisms of methamphetamine on nerve terminals. Key words: methamphetamine; dopamine; serotonin; exitotoxicity 甲基苯丙胺(methamphetamine, Meth) 属于苯 1　甲基苯丙胺的急性奖赏作用 丙胺类兴奋剂，是一种在麻黄素化学结构基础上衍 甲基苯丙胺的急