医药-脑源性神经营养因子跟缺血性脑损伤.pdfVIP

2004 6 12 6 # 433 # ## 脑源性神经营养因子与缺血性脑损伤 刘崴 程焱 王虔 ( BDNF) , , BDNF 2+ Ca BaxBc-l 2 ; ; ; ; Bc-l 2 Brain-derived Neurotraphic Factor and Cerebral Ischemic In- jury Liu Wei, Cheng Yan, Wang Qian Institute of Neurology , Tianj in General Hosp ital, Tianj in Medical Uni ersity , Tianj in 300052, China ABSTRACT Brain- derived neurotrophic actor ( BDNF) is one o the members in the nerve growth actor ( NGF) amily. It can prevent neurons death ollowing cerebral ischemia and thus improve the prognosis. This article discusses the construction, unct ion , distribution o BDNF, and its possible protective mechanisms , including inhibiting excitory neurotoxicity; regulating the balance o calcium in neurons, and the expreesion o Bax and Bcl- 2. KE WORD brain- derived neurotraphic actor u cerebral ischemia u gene therapy u apoptosis u Bc-l 2 ( BDNF) , BDNF 2 ( NGF) , 1982 Bard , BDNF p75NTR( ) , [ 1] , , , (TNFR) , ; 1 BDNF TrkB TrkB ( ) , 1. 1 BDNF (Trk) , BDNF NT-4 ( neurotrophin actor, NTF) , NT- 3 , TrkB , TrkB , , , BDNF , [ 2] BDNF TrkB , NGF , TrkB NGF , BDNF mRNA , TrkB ( , , [ 3] TrkB) Trk , BDNF mRNA NGF mR- p75NTR 2