W6-感染与免疫PPT课件.pptVIP

Infection and Immunity;*;手足口病皮疹分布: 1. 颊粘膜和手指 2. 手掌 3. 足底 4. 唇粘膜 5.咽峡炎。 个别患者可引起心肌炎、肺水肿、无菌性脑膜脑炎等并发症!;A human syndrome caused by intestinal viruses of the Picornaviridae family. The most common strains causing HFMD are Coxsackie A virus and Enterovirus 71 (EV71).; Non-enveloped, positive-stranded RNA viruses with an icosahedral (20) capsid Genome RNA has a protein primer for transcription by RNA polymerase;??? 手足口病的流行病学;*;I) Common pathogens;Adenovirus;100 nm;*;;Human Immunodeficiency Virus (HIV);II) Host defense system;Fusion? of a virus with the plasma membrane after attachment to? a cell surface receptor;Receptors;;;Course of Immune Response during Influenza Infection ;*;Goff (2004, Mol. Cell);*;*;*;*;*;;*;;*;*;Immunological Memory;III) Viral escape mechanisms;Escape by Hiding;Escape by Latency;Escape by antigenicity changes;Antigenshift;Escape by Subverting Antigen Processing and Antigen Presentation;Escape by Destruction of Immune Cells;Inhibition of Target Cell Lysis;Inhibition of Natural Killer Cell Activity;Inhibition of Interferons;Cytokine Mimetics;Inhibition of Complement Activation;MCMV encodes a crystallized fragment (Fc) ? receptor–like molecule that subverts antibody-mediated lysis of infected cells;Immune tolerance;immunopathology!;Cellular immunity Antibody and complement Cytokines;细胞因子在感染免疫病理中的作用;Molecular mimicry: a viral antigen shows sequence homology with a self-protein Immune complexes Abnormal regulation of T-cell responses;V) Immunological Prevention and Therapy ;Vaccination;BACTERIAL INFECTION;Septic shock Bacterial infection induced acute inflammatory states ;The LPS-induced TLR4 pathways ;Inflammatory cytokines and septic shock;*;Helicobacter pylori : inhabits various areas of the stomach and duodenum. causes a chronic low-level inflammation of the stomach lining is strongly linked to the development of duodenal and gastric ulcers and stomach cancer. ;*;In susceptible hosts, Helicobacter pylori colonizes the stomach and in