益气化痰颗粒联合羧甲司坦减少慢性阻塞性肺疾病急性加重临床的研究.docVIP

益气化痰颗粒联合羧甲司坦减少慢性阻塞性肺疾病急性加重临床的研究 　　摘要：目的 观察益气化痰颗粒联合羧甲司坦减少慢性阻塞性肺疾病（COPD）稳定期患者急性加重的疗效及安全性。方法 纳入COPD稳定期气虚或兼痰阻/血瘀证患者108例，采用区组随机法分为观察组和对照组各54例。对照组口服羧甲司坦并按需吸入支气管舒张剂，观察组在此基础上联合益气化痰颗粒冲服，疗程24周。观察2组治疗期间COPD急性加重次数与程度及治疗前后中医证候评分、肺功能、6 min步行距离变化。结果 观察组平均急性加重总次数（0.33±0.55）低于对照组（0.62±0.71），平均重度急性加重次数（0.12±0.33）低于对照组（0.28±0.45），差异均有统计学意义（P0.05）；治疗前后症状评分比较，观察组中医证候总分、喘息/呼吸困难评分、气短乏力评分及6 min步行距离的改善均优于对照组（P0.05）；治疗安全性好。结论 益气化痰颗粒联合羧甲司坦治疗COPD稳定期患者，可有效减少COPD急性加重的次数及程度，改善患者中医证候评分及6 min步行距离。 　　关键词：益气化痰颗粒；慢性阻塞性肺疾病；急性加重；中西医结合疗法 　　DOI：10.3969/j.issn.1005-5304.2015.08.012 　　中图分类号：R259.639 文献标识码：A 文章编号：1005-5304（2015）08-0043-04 　　Clinical Study of Yiqi Huatan Granules Combined with Carbocisteine to Reduce Acute Exacerbation of Chronic Obstructive Pulmonary Disease GAO Feng， WU Wei， WANG Bin， WANG Wei， ZHANG Li-chun， LI Shan （Wangjing Hospital， China Academy of Chinese Medical Sciences， Beijing 100102， China） 　　Abstract：Objective To observe the efficacy and safety of Yiqi Huatan Granules combined with carbocisteine to reduce the acute exacerbation of chronic obstructive pulmonary disease （COPD）. Methods Totally 108 patients in the stationary phase of COPD with qi deficiency or merging phlegm blockage/blood stasis syndrome were randomly divided into two groups. Patients in the control group were treated with carbocisteine and inhaled bronchodilators on-demand， while patients in the treatment group were treated with Yiqi Huatan Granules combined with carbocisteine and bronchodilators for 24 weeks. Times and severity of acute exacerbations of COPD， TCM syndrome scores， lung function， and 6-minute walking distances of the two groups during the treatment period were observed. Results The average times of acute exacerbations of COPD in the treatment group （0.33 ± 0.55） were fewer than the control group （0.62 ± 0.71）；the average times of severe acute exacerbations of COPD in the treatment group （0.12 ± 0.33） were fewer than the control group （0.28 ± 0.45）， with statistical significance （P 　　Key wo