APC及抗原递呈(英文)-精选（公开课件）.pptVIP

Antigen uptaking pathways by DC macropinocytosis receptor-mediated endocytosis phagocytosis Endosome MHC class II、HLA-DM, and exogenous antigenic peptide are found in abundance. Antigen processing compartment （2）Degradation of protein antigen Endopeptidase  Exopeptidase Peptides containing 12-20 amino acid residues Calnexin Ia associated invariant chain(Ii chain): Class II associated invariant chain peptide （CLIP） Form nonamer with ?, ? chain Enter endosome through trans-Golgi network MHC class II molecules are transported from ER to endosome. Function of Ii To prevent degradation of MHC class II molecule during its transportation CLIP binds to the grooves in MHC class II molecule （4）Ii degradation in endosome （5）Class II molecules peptide loading Class II molecules peptide loading （6）Presentation of exogenous antigens Exocytic vesicles Expressed on APC Recognized by CD4+ T cells Antigen Phagocytosis Macrophage Antigen internalization Endosome/lysosome B cell Antigenic peptide-MHC class 2 molecule complex Golgi complex ER αβIi complex Ii chain Antigenic peptide-MHC class 2 molecule complex Presentation of exogenous antigens Characteristics Endogenous pathway exogenous pathway Presenting molecule MHC-I MHC-II Responding T cells CD8＋ T cells CD4＋ T cells Antigen resources endogenously synthesized exogenous uptaken Synthesizing region of antigen peptides proteosome endosome Chaperon Calnexin, TAP, tapasin Calnexin, Ii chain Presenting cells all nucleated cells professional APC Comparison of endogenous and exogenous antigen-presenting pathway * * Antigen-presenting cells and antigen presentation 1.Nature of antigen-presenting cells 2. Antigen processing and presentation Antigen Presenting Cell (APC) Section 1