常见的第3章毒作用机制.pptVIP

歧化反应：也称自身氧化还原反应。是氧化还原反应的一种类型。在歧化反应中，同一种元素的一部分原子(或离子)被氧化；另一部分原子（或离子）被还原。 * * 脂质自由基 (L?)变化 formed is converted successively to lipid peroxyl radical (LOO?) by oxygen fixation, lipid hydroperoxide (LOOH) by hydrogen abstraction, and lipid alkoxyl radical (LO?) by the Fe(II)- catalyzed Fenton reaction. Subsequent fragmentation gives rise to hydrocarbons such as ethane and reactive aldehydes such as 4-hydroxynon-2-enal and malondialdehyde. Formation of a bulky adduct at guanine N-7 destabilizes the N-glycosylic bond, inducing depurination. Depurination results in apurinic sites that are mutageni