雷帕霉素药物涂层支架CYPHER plus+治疗冠脉前降支长病变临床的应用.docVIP

雷帕霉素药物涂层支架CYPHER plus+治疗冠脉前降支长病变临床的应用 　　【摘要】 目的 评价雷帕霉素药物涂层支架(CYPHER plus+,Cordis)治疗冠状动脉前降支长病变的长期临床疗效。方法 前降支长病变(病变长度≥20 mm)患者46例置入CYPHER plus+支架56个,病变长度20~45 mm,平均(25.2±7.8)mm,术前病变狭窄程度(87.9±7.5)%;血管直径(3.0±0.75)mm。其中前降支病变28 mm10例,置入2个支架重叠,1个长支架覆盖病变36例。结果 手术即刻成功率100%,术后造影病变残余狭窄(3.5±2.8)%,支架覆盖病变完全,支架近、远端无夹层,血流TIMI 3级。随访6个月,心绞痛消失43例,术后6个月复查冠状动脉造影,无血管再狭窄发生。结论 雷帕霉素药物涂层支架治疗前降支长病变是解决前降支长病变安全有效的方法。 　　【关键词】冠状动脉病变;前降支;药物涂层支架;雷帕霉素 　　 　　The clinical experience of CYPHER plus+ stent in long lesion of left anterior descending artery 　　SUN Jun-hua,YUAN Yi-qiang,LIU Huai-lin,et al.Department of cardiology,The Seventh peopels Hospital of zhengzhou450000,China 　　【Abstract】 Objective To evaluate the clinical effect of CYPHER plus+ Cordis(Rapamycin)plus stent in treatment of left anterior decending(LAD)long leision.Methods LAD long leision.(the length of lension≥20 mm),46 patients with coronary heart disease(CAD)were treated with(CYPHER plus+,Cordis)stent and 56 stent were planted in 46 case LAD leision.the length of lension was from20 mm to 45 mm,(25.2±7.8)mm,the degree of stenosis before procedure was(87.9±7.5)%,and the vessel diameter before procedure was(3.0±0.75)mm.10 lesions over 28 mm long were teated with two overlapped stents to cover the whole lesion,36leision were teated with only one stent.Results Immedeiate procedure success rate was 100%,with residual stenosis of(3.5±2.8)%,All the lesions were covered fully by stents and the coronary flow reached TIMI grade three.No new dissection was observed in the optimal of stents.During the 6 months follow-up,the symptom of angina was disappeared in 43 patients.all patients received CAG in 6 months and no restenosis was observed.Conclusion Duge eluting the stents(CYPHER plus+,Cordis)implantation is a safe and efficient therapy in treating patients with LAD long leision. 　　【Key words】Duge eluting the stents; Left anterior decending; Rapamycin 　　 　　经皮冠状动脉介入治疗(PCI)是治疗冠心病的重要方法,目前冠状动脉内支架已广泛用于临床。支架明显地改善了经皮冠状动脉成形术(PTCA)引起的急性血管闭塞及再狭窄