甘露醇在外伤性蛛网膜下腔出血患者降低.docVIP

甘露醇在外伤性蛛网膜下腔出血患者降低 　　[摘要] 目的 探讨甘露穿在外伤性蛛网膜下腔出血患者降低颅内压中的应用效果。方法 方便选取2014年8月―2017年8月该院收治的116例外伤性蛛网膜下腔出血颅内压升高患者为研究对象，依据治疗方法不同分为实验组（甘露醇，58例）和对照组（尼莫地平，58例）。对比观察两组疗效，统计用药后起效时间、维持时间、颅内压下降幅度等指标，评价药物安全性。结果 实验组治疗有效率93.10%，不良反应率3.45%，与对照组比较差异无统计学意义（χ2=2.17、0.81，P0.05）。实验组起效时间（17.4±3.1）min，与对照组比较差异有统计学意义（t=4.02，P0.05）。结论 外伤性蛛网膜下腔患者静脉滴注甘露醇能有效降低颅内压，起效迅速、应用安全，值得临床推广使用。 　　[关键词] 外伤性蛛网膜下腔出血；颅内压升高；甘露醇 　　[中图分类号] R743 [文献标识码] A [文章编号] 1674-0742（2018）03（a）-0114-03 　　Application of Mannitol in Reducing Intracranial Pressure in Patients with Traumatic Subarachnoid Hemorrhage 　　ZHANG Ye-si 　　Department of Brain Surgery， Xuyi Hospital of TCM， Xuyi， Jiangsu Province， 211700 China 　　[Abstract] Objective This paper tries to investigate the effect of mannitus in reducing intracranial pressure in patients with traumatic subarachnoid hemorrhage. Methods From August 2014 to August 2017， 116 patients with traumatic cerebral hemorrhage were enrolled in this study. According to the different treatment methods， the experimental group（mannitol 58 cases） and control group （Nimodipine， 58 cases）. The curative effect was evaluated by comparing the curative effect of the two groups， the time of onset， the time of maintenance and the decrease of intracranial pressure. Results In the experimental group， the effective rate was 93.10% and the adverse reaction rate was 3.45%. There was no significant difference compared with the control group （χ2=2.17，0.81， P0.05）. The onset time of the experimental group （17.4±3.1） min， compared with the control group， the difference was statistically significant（t=4.02， P0.05）. Conclusion Intravenous infusion of mannitol in traumatic subarachnoid patients can effectively reduce intracranial pressure， rapid onset， safe application and which is worthy of clinical use. 　　[Key words] Traumatic subarachnoid hemorrhage； Intracranial pressure； Mannitol 　　外??性蛛网膜下腔出血指外界暴力造成脑组织挫裂伤，导致脑底部或表面细小血管损伤出血，血液流入蛛网膜下腔后引起的以剧烈头痛、呕吐、脑膜刺激征等特征性表现的临床综合征[1]。颅内压增高是外伤性蛛网膜下腔出血常见病理征象，早期正确处理颅内高压对挽救生